ArticleProceedings of the National Academy of Sciences of the United States of America1997
The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 72 citations in OpenAlex.
- A common structural mechanism for RNA recognition by the SF3B complex in mRNA splicing and export.Nucleic acids research · 2025Article
- ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs.The EMBO journal · 2019Article
- Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.Retrovirology · 2014Article
- Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.Nucleic acids research · 2013Article
- Searching for nuclear export elements in hepatitis D virus RNA.World journal of virology · 2013Article
- Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export.Nucleic acids research · 2013Article
- Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.Nucleic acids research · 2012Article
- Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.PloS one · 2012Article
- Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The presence of multiple introns is essential for ERECTA expression in Arabidopsis.RNA (New York, N.Y.) · 2011Article
- Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-α 1 mRNA.Medical molecular morphology · 2010Article
- A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence.The EMBO journal · 2010Article
- Knockdown of SLBP results in nuclear retention of histone mRNA.RNA (New York, N.Y.) · 2009Article
- Where do introns come from?PLoS biology · 2008Article
- Two G-rich regulatory elements located adjacent to and 440 nucleotides downstream of the core poly(A) site of the intronless melanocortin receptor 1 gene are critical for efficient 3' end processing.Molecular and cellular biology · 2007Article
- A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts.The EMBO journal · 2005Article
- Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes.Nucleic acids research · 2005Article
- Nuclear export of metazoan replication-dependent histone mRNAs is dependent on RNA length and is mediated by TAP.RNA (New York, N.Y.) · 2005Article
- RNA length defines RNA export pathway.Genes & development · 2004Article
- Viral regulation of mRNA export.Journal of virology · 2004Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Histone mRNAs are naturally intronless and accumulate efficiently in the cytoplasm. To learn whether there are cis-acting sequences within histone genes that allow efficient cytoplasmic accumulation of RNAs, we made recombinant constructs in which sequences from the mouse H2a gene were cloned into a human beta-globin cDNA. By using transient transfection and RNase protection analysis, we demonstrate here that a 100-bp sequence within the H2a coding region permits efficient cytoplasmic accumulation of the globin cDNA transcripts. We also show that this sequence appears to suppress splicing and can functionally replace Rev and the Rev-responsive element in the cytoplasmic accumulation of unspliced HIV-1-related mRNAs. Like the Rev-responsive element, this sequence acts in an orientation-dependent manner. We thus propose that the sequence identified here may be a member of the cis-acting elements that facilitate the cytoplasmic accumulation of naturally intronless gene transcripts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.