ArticleProceedings of the National Academy of Sciences of the United States of America1997
Characterization of human telomerase complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3.Genes and immunity · 2004Trial
- The Bacterial Ro60 Protein and Its Noncoding Y RNA Regulators.Annual review of microbiology · 2020Review
- Article
- Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin.Nucleic acids research · 2012Article
- The Ro 60 kDa autoantigen: insights into cellular function and role in autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2004Review
- Design of a ribozyme targeting human telomerase reverse transcriptase and cloning of it's gene.World journal of gastroenterology · 2003Article
- Interference footprinting analysis of telomerase elongation complexes.Molecular and cellular biology · 2000Article
- Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer.The American journal of pathology · 1998Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomerase, a ribonucleoprotein complex, adds hexameric repeats called "telomeres" to the growing ends of chromosomal DNA. Characterization of mammalian telomerase has been elusive because of its low level of expression. We describe a bioinformatics approach to enrich and characterize the human telomerase complex. Using local sequence homology search methods, we detected similarity of the Tetrahymena p80 subunit of telomerase with the autoantigen Ro60. Antibodies to Ro60 immunoprecipitated the telomerase activity. Ro60 and p80 proteins were cross-recognizable by antibodies to either protein. Telomerase activity and the RNA component of telomerase complex were localized to a doublet in a native gel from the Ro60 antibody-precipitated material. The enriched material showed specific binding to a TTA GGG probe in vitro in an RNA template-dependent manner. Polyclonal antibodies to the doublet also immunoprecipitated the telomerase activity. These results suggest an evolutionary conservation of the telomerase proteins.
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