ArticleThe Journal of experimental medicine1997
Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 65 citations in OpenAlex.
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- Charged substrate treatment enhances T cell mediated cancer immunotherapy.Nature communications · 2025Article
- Early Growth Response Factor 1 in Aging Hematopoietic Stem Cells and Leukemia.Frontiers in cell and developmental biology · 2022Review
- Nab2 maintains thymus cellularity with aging and stress.Molecular immunology · 2017Article
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
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- Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
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- Chromatin remodeling complex NURF regulates thymocyte maturation.Genes & development · 2011Article
- The essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signaling.Molecular and cellular biology · 2011Article
- Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.Seminars in immunology · 2010Review
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- The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.Nature immunology · 2009Article
- Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.Nuclear receptor signaling · 2009Review
- Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development.Advances in developmental biology (Amsterdam, Netherlands) · 2006Article
- c-Myb regulates the proliferation of immature thymocytes following beta-selection.The EMBO journal · 2000Article
- Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development.The Journal of clinical investigation · 1999Article
- The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.The Journal of experimental medicine · 1998Article
- Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1).The Journal of experimental medicine · 1998Article
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
The early growth response (Egr)-1 is a zinc finger-containing transcription factor belonging to the immediate-early genes. Its expression in CD4/CD8 double negative (DN) immature thymocytes suggests that Egr-1 expression may be involved in early thymocyte development. In transgenic mice overexpressing Egr-1 in a recombinase-activating gene-deficient background, thymocytes bypassed the block at the CD25+CD44- DN stage and matured to the immature CD8 single-positive (ISP) cell stage, but not further to the CD4/CD8 double-positive (DP) cell stage. When these mice were irradiated, thymocytes did develop to the DP stage, suggesting transcriptional induction of additional genes by irradiation that are required to promote thymocyte development from the ISP to the DP stage. These results provide genetic evidence for two distinct steps during early thymocyte development from the CD25+CD44- DN to the DP stage. The first step, from the CD25+CD44- DN to the ISP stage, can be entirely promoted by overexpression of Egr-1.
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