ArticleThe Journal of clinical investigation1997
Biomechanical coupling in renin-releasing cells.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- The neurobiology of thirst and salt appetite.Neuron · 2024Review
- Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases.Frontiers in cardiovascular medicine · 2023Review
- Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.Cell & bioscience · 2022Article
- Renin Activity in Heart Failure with Reduced Systolic Function-New Insights.International journal of molecular sciences · 2019Review
- TRPV4 participates in pressure-induced inhibition of renin secretion by juxtaglomerular cells.The Journal of physiology · 2016Article
- Salt feedback on the renin-angiotensin-aldosterone system.Pflugers Archiv : European journal of physiology · 2015Review
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- Regulation of renin secretion by renal juxtaglomerular cells.Pflugers Archiv : European journal of physiology · 2013Review
- Recent advances involving the renin-angiotensin system.Experimental cell research · 2012Review
- Angiotensin inhibition and longevity: a question of hydration.Pflugers Archiv : European journal of physiology · 2011Review
- Methods for imaging Renin-synthesizing, -storing, and -secreting cells.International journal of hypertension · 2010Article
- Maternal diabetes modulates renal morphogenesis in offspring.Journal of the American Society of Nephrology : JASN · 2008Article
- A new cardiac MASTer switch for the renin-angiotensin system.The Journal of clinical investigation · 2006Article
- Prostanoids and blood pressure: which way is up?The Journal of clinical investigation · 2004Review
- Thyroid Hormone Stimulates Renin Gene Expression Through the Thyroid Hormone Response Element.Hypertension (Dallas, Tex. : 1979) · 2001Article
- Effect of renal perfusion pressure on renal function, renin release and renin and angiotensinogen gene expression in rats.The Journal of physiology · 1999Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The renin-angiotensin system is a major regulatory system controlling extracellular fluid volume and blood pressure. The rate-limiting enzyme in this hormonal cascade is renin, which is synthesized and secreted into the circulation by renal juxtaglomerular (JG) cells. The renal baroreceptor is a key physiologic regulator of renin secretion, whereby a change in renal perfusion pressure is sensed by these cells and results in a change in renin release. However, the mechanism, direct or indirect, underlying pressure transduction is unknown. We studied the direct application of mechanical stretch to rat JG cells and human renin-expressing (CaLu-6) cells on the release of renin. JG cells released a low level of baseline renin, comprising < 5% of their total renin content. By contrast, renin secretion from CaLu-6 cells comprised approximately 30% of cellular stores, yet was also stimulated twofold by 10 microM forskolin (P </= 0.001). In JG cells, mechanical stretch inhibited basal renin release by 42% (P < 0.01) and forskolin-stimulated renin release by 25% (P < 0.05). In CaLu-6 cells, stretch inhibited basal- and forskolin-stimulated renin release by 30 and 26%, respectively (both P < 0.01). Northern blot analysis demonstrated a stretch-induced reduction in baseline renin mRNA accumulation of 26% (P < 0.05) in JG and 46% (P < 0.05) in CaLu-6 cells. The data demonstrate that mechanical stretch in renin-releasing cells inhibits basal and stimulated renin release accompanied by a decrease in renin mRNA accumulation. Further studies will be necessary to characterize the intracellular events mediating biomechanical coupling in renin-expressing cells and the relationship of this signaling pathway to the in vivo baroreceptor control of renin secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.