ReviewTrends in neurosciences1997
T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms.
Review in Trends in neurosciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- The neuropathobiology of multiple sclerosis.Nature reviews. Neuroscience · 2024Review
- Protective Role of a New Polysaccharide Extracted fromBioMed research international · 2021Article
- Multiple sclerosis.Nature reviews. Disease primers · 2018Review
- The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host's Defense Strategy against Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Review
- Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis.Journal of neuroinflammation · 2015Article
- Autoimmune and autoinflammatory mechanisms in uveitis.Seminars in immunopathology · 2014Review
- Treatment of chronic inflammatory demyelinating polyneuropathy: from molecular bases to practical considerations.Autoimmune diseases · 2014Review
- Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation.Mediators of inflammation · 2013Review
- The impact of the extracellular matrix on inflammation.Nature reviews. Immunology · 2010Review
- The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review.International journal of inflammation · 2010Article
- Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients.Clinical and experimental immunology · 2005Article
- [New understanding of the immunopathogenesis of multiple sclerosis].Der Nervenarzt · 2003Review
- New immunopathologic insights into multiple sclerosis.Current neurology and neuroscience reports · 2003Review
- Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains.Brain pathology (Zurich, Switzerland) · 2000Article
- Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination.The EMBO journal · 2000Article
- Apoptosis of CD4+ T cells occurs in experimental autoimmune anterior uveitis (EAAU).Clinical and experimental immunology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied T-cell apoptosis in animal models of human autoimmune disorders of the nervous system and in other tissues devoid of specialized immune-defense mechanisms. Our data suggest that the CNS has high potential for elimination of T-cell-dependent inflammation, whereas this mechanism is less effective in the PNS, and is almost absent in other tissues such as muscle and skin. Interestingly, several conventional and novel immunotherapeutic approaches, such as glucocorticosteroid and high-dose antigen therapy, induce T-cell apoptosis in situ. In vitro experiments suggest different scenarios for the mechanisms by which specific cellular and humoral elements in the nervous system synergize and sensitize T cells for apoptosis in vivo. We also discuss regulatory, proapoptotic mechanisms, such as the Fas-FasL system and galectin-I, that have been utilized in other tissues to mediate immune protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.