ArticleJournal of cancer research and clinical oncology1997
Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening.
Article in Journal of cancer research and clinical oncology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
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- Global Proteomic Profile Integrated to Quantitative and Morphometric Assessment of Enteric Neurons: Investigation of the Mechanisms Involved in the Toxicity Induced by Acute Fluoride Exposure in the Duodenum.Neurotoxicity research · 2021Article
- Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer.Nucleic acids research · 2015Article
- Screening of potential diagnostic markers and therapeutic targets against colorectal cancer.OncoTargets and therapy · 2015Article
- Overexpression of matriptase correlates with poor prognosis in esophageal squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2014Article
- Matriptase is involved in ErbB-2-induced prostate cancer cell invasion.The American journal of pathology · 2010Article
- A putative role for microRNA-205 in mammary epithelial cell progenitors.Journal of cell science · 2010Article
- Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?Cancer gene therapy · 2008Review
- Expression of SNC73, a transcript of the immunoglobulin alpha-1 gene, in human epithelial carcinomas.World journal of gastroenterology · 2007Article
- Ribosomal proteins and colorectal cancer.Current genomics · 2007Article
- What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor?Journal of Zhejiang University. Science. B · 2007Review
- Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract.World journal of gastroenterology · 2005Article
- Effect of SNC19/ST14 gene overexpression on invasion of colorectal cancer cells.World journal of gastroenterology · 2005Article
- Expression of ST13 in colorectal cancer and adjacent normal tissues.World journal of gastroenterology · 2005Article
- Expression of a novel immunoglobulin gene SNC73 in human cancer and non-cancerous tissues.World journal of gastroenterology · 2003Article
- Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins.BMC neuroscience · 2002Article
- Mutagen sensitivity and p53 expression in colorectal cancer in China.Postgraduate medical journal · 2001Article
- Orthologs in Arabidopsis thaliana of the Hsp70 interacting protein Hip.Cell stress & chaperones · 2001Article
- Subtractive hybridization--genetic takeaways and the search for meaning.International journal of experimental pathology · 2000Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an attempt to seek out new factors that are related to colorectal carcinogenesis at the molecular level, subtractive hybridization between cDNA of normal mucosal tissues and mRNA of colorectal carcinoma tissues was performed. Subsequent screenings of the cDNA libraries, constructed from normal mucosal tissues, using the "subtractive probes" generated a total of 46 clones that were expressed in normal mucosa but were either expressed at a significantly reduced level or not expressed at all in cancer tissues. Partial nucleotide sequences of all of these cDNA clones were determined, and sequence homology analyses were performed with the Genbank database. Of the 46 cDNA samples, 44 contained substantial sequence homologies with 32 immunoglobulin gene fragments, a helix-loop-helix basic phosphoprotein gene, an acidic ribosomal phosphoprotein P2 gene, a BLR1 gene for Burkitt's lymphoma receptor 1 gene, D5S419 DNA segment containing (C-A) repeats, a glucokinase (GCK) gene, a Na+, K+-ATPase alpha-subunit gene, a histocompatibility system HLA-DR heavy-chain gene, a dystrophic gene, a mucin (MUC2) gene, a mu-glutathione S-transferase gene, a Menkes disease protein gene, and a 40-kDa keratin intermediate filament precursor gene. The remaining two cDNA clones (now registered under GenBank accession numbers U17714 and U20428) showed few (less than 60%) sequence homologies with any known sequences in the GenBank database and, therefore, may represent novel genes whose expression was down-regulated in human colorectal carcinomas. The possible clinical significance of these findings and the involvement of these two genes in the carcinogenesis of colorectal as well as other cancers are being investigated.
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