ReviewMolecular biology reports1997
Chromatin domains and nuclear compartments: establishing sites of gene expression in eukaryotic nuclei.
Review in Molecular biology reports, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- From chromosomal protein disorder to chromatin phase separation.Epigenetics & chromatin · 2026Review
- Transcription factories.Frontiers in genetics · 2012Article
- Kaposi's Sarcoma-Associated Herpesvirus Genome Replication, Partitioning, and Maintenance in Latency.Frontiers in microbiology · 2012Article
- Transcription factories in the context of the nuclear and genome organization.Nucleic acids research · 2011Review
- Cis-regulation of microRNA expression by scaffold/matrix-attachment regions.Nucleic acids research · 2011Article
- RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.The EMBO journal · 2011Article
- High-level transgene expression by homologous recombination-mediated gene transfer.Nucleic acids research · 2011Article
- Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure.Nucleic acids research · 2010Article
- Modelling the correlation between the activities of adjacent genes in Drosophila.BMC bioinformatics · 2005Article
- Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.Oncogene · 2004Review
- In silico identification of metazoan transcriptional regulatory regions.Die Naturwissenschaften · 2003Review
- FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles.Molecular biology of the cell · 2002Article
- Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments.The Journal of cell biology · 2000Article
- Rearrangement of chromatin domains during development in Xenopus.Genes & development · 2000Article
- Use of matrix attachment regions (MARs) to minimize transgene silencing.Plant molecular biology · 2000Review
- Intranuclear anchoring of repetitive DNA sequences: centromeres, telomeres, and ribosomal DNA.The Journal of cell biology · 1999Article
- Spatial relationship between transcription sites and chromosome territories.The Journal of cell biology · 1999Article
- Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle.The EMBO journal · 1998Article
- Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Establishing sites of transcription in the nuclei of higher eukaryotic cells is a very complex process. Before transcription can begin, a series of transcription factors must associate with their recognition motifs, within promoters and more remote activating sequences. Once bound, these factors and associated proteins are believed to form a complex that positions the RNA polymerase holoenzyme so that transcription can commence. As a consequence, active genes assume a specialized chromatin state across regions that define functional domains. Global nuclear architecture appears to stabilize these active domains by providing local environments dedicated to gene expression. As the spatial organization of these sites is unaffected by the removal of most chromatin they must be associated with a structural network. This nucleoskeleton, the associated transcription 'factories' and chromatin loops that arise as DNA binds proteins within factories now appear to be fundamental features of nuclear structure in higher eukaryotes. I argue that concentrating proteins needed to perform different steps of RNA synthesis within specialized nuclear compartments will be important in orchestrating events required for efficient gene expression.
Indexed as
Identifiers
9291094What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.