ReviewMolecular biology reports1997
Nuclear matrix, dynamic histone acetylation and transcriptionally active chromatin.
Review in Molecular biology reports, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 94 citations in OpenAlex.
- MATR3-antisense LINE1 RNA meshwork scaffolds higher-order chromatin organization.EMBO reports · 2023Article
- Dynamics of nuclear matrix attachment regions during 5BMC genomics · 2022Article
- Little imaginal discs, a Trithorax group member, is a constituent of nuclear matrix ofJournal of biosciences · 2018Article
- Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells.Epigenetics · 2013Article
- Heterochromatin as an incubator for pathology and treatment non-response: implication for neuropsychiatric illness.The pharmacogenomics journal · 2012Review
- The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44.PloS one · 2012Article
- The torsional state of DNA within the chromosome.Chromosoma · 2011Review
- Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster.Journal of biosciences · 2011Article
- Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis.Molecular biology reports · 2010Article
- C/EBPε participates in all-trans retinoic acid induction of PI3Kγ in U937 cells via an intronic matrix attachment region sequence.Molecular biology reports · 2010Article
- Silencing by nuclear matrix attachment distinguishes cell-type specificity: association with increased proliferation capacity.Nucleic acids research · 2009Article
- Selective anti-leukaemic activity of low-dose histone deacetylase inhibitor ITF2357 on AML1/ETO-positive cells.Oncogene · 2008Article
- The 8;21 translocation in leukemogenesis.Oncogene · 2004Review
- Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.Oncogene · 2004Review
- Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors.Genes & development · 2002Article
- Matrix attachment region-dependent function of the immunoglobulin mu enhancer involves histone acetylation at a distance without changes in enhancer occupancy.Molecular and cellular biology · 2001Article
- Article
- Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear matrix, the RNA-protein skeleton of the nucleus, has a role in the organization and function of nuclear DNA. Nuclear processes associated with the nuclear matrix include transcription, replication and dynamic histone acetylation. Nuclear matrix proteins, which are tissue and cell type specific, are altered with transformation and state of differentiation. Transcription factors are associated with the nuclear matrix, with the spectra of nuclear matrix bound factors being cell type specific. There is compelling evidence that the transcription machinery is anchored to the nuclear matrix, and the chromatin fiber is spooled through this complex. Transcriptionally active chromatin domains are associated with dynamically acetylated histones. The energy exhaustive process of dynamic histone acetylation has several functions. Acetylation of the N-terminal tails of the core histones alters nucleosome and higher order chromatin structure, aiding transcriptional elongation and facilitating the binding of transcription factors to nucleosomes associated with regulatory DNA sequences. Histone acetylation can manipulate the interactions of regulatory proteins that bind to the N-terminal tails of the core histones. Lastly, dynamic acetylation may contribute to the transient attachment of transcriptionally active chromatin to the nuclear matrix. Reversible histone acetylation is catalyzed by histone acetyltransferase and deacetylase, enzymes associated with the nuclear matrix. The recent isolation and characterization of histone acetyltransferase and deacetylase reveals that these enzymes are related to transcriptional regulators, providing us with new insights about how these enzymes are targeted to nuclear matrix sites engaged in transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.