ArticleJournal of the Royal Society of Medicine1997
Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients.
Article in Journal of the Royal Society of Medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 9 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Occupational solar exposure and basal cell carcinoma. A review of the epidemiologic literature with meta-analysis focusing on particular methodological aspects.European journal of epidemiology · 2024Pooled it
- Teledermatology for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Optical coherence tomography for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Reflectance confocal microscopy for diagnosing keratinocyte skin cancers in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults.The Cochrane database of systematic reviews · 2018Pooled it
- High-frequency ultrasound for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Sun protection for preventing basal cell and squamous cell skin cancers.The Cochrane database of systematic reviews · 2016Pooled it
- Smoking and risk of skin cancer: a prospective analysis and a meta-analysis.International journal of epidemiology · 2012Pooled it
- Association between statin use and risk for keratinocyte carcinoma in the veterans affairs topical tretinoin chemoprevention trial.Annals of internal medicine · 2009Trial
- Gli pathway-targeted Co(iii) Schiff base complexes inhibit migration of basal cell carcinoma cells.RSC advances · 2025Article
- Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility.Genome medicine · 2021Article
- Article
- Periocular basal cell carcinoma - clinical perspectives.Oncology reviews · 2020Article
- Development of Multiple-Lesion Basal Cell Carcinoma of the Skin: A Comprehensive Review.Sisli Etfal Hastanesi tip bulteni · 2019Review
- Metal arc welding and the risk of skin cancer.International archives of occupational and environmental health · 2017Article
- Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art.Nano reviews & experiments · 2017Review
- Pathway analysis of expression-related SNPs on genome-wide association study of basal cell carcinoma.Oncotarget · 2016Article
- Early investigation by fluor-18-fluorodeoxyglucose positron emission tomography of a metastatic basal cell carcinoma presenting with spinal cord compression: A case report.JAAD case reports · 2015Article
- Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors.Biologics : targets & therapy · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basal cell carcinoma (BCC) is the commonest malignant neoplasm in white people. We present a large UK case-control study in which conditional logistic regression analysis of age-matched and gender-matched data sets was used to compare, first, cases with controls (n = 403) and second, patients having multiple BCC with those having a single BCC (n = 278). Eye/hair colour, occupation, skin type, social class, tumour site at presentation and smoking history were assessed. Social class 1/2, skin type 1, red/blonde hair and blue/green eyes were all related to BCC risk, social class most strongly (odds ratio 2.36, P = 0.007). Truncal site at presentation was a risk factor for the development of multiple BCC (odds ratio 4.03, P = 0.002). These data support the view that genetically mediated differences in ultraviolet responsiveness are important in BCC, though the scale of their effect is small. They may be exploitable in primary and secondary prevention as well as giving insights into pathogenesis. In particular, the fact that patients presenting with a truncal tumour are at increased risk of further BCC suggests that intermittent exposure in genetically predisposed individuals may contribute to a cancer susceptibility syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.