Trial reportHeart (British Cardiac Society)1997
Non-invasive measurement of endothelial function: effect on brachial artery dilatation of graded endothelial dependent and independent stimuli.
Trial report in Heart (British Cardiac Society), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04539093 (Assessment of Endothelial Function in Patients With Advanced Heart Failure Requiring Mechanical Circulatory Support), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Endothelial Function in Patients With Advanced Heart Failure Requiring Mechanical Circulatory Support
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test.Journal of visualized experiments : JoVE · 2016Guideline
- Effects of exercise training on arterial function in type 2 diabetes mellitus: a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2013Pooled it
- Assessment of flow-mediated dilation in humans: a methodological and physiological guideline.American journal of physiology. Heart and circulatory physiology · 2011 · on this mapGuideline
- IL-6 Response to Psychosocial Stress Predicts 12-month Changes in Cardiometabolic Biomarkers in Perimenopausal Women.The Journal of clinical endocrinology and metabolism · 2020Trial
- Ultrasound measurement of peripheral endothelial dysfunction in type 2 diabetic patients: correlation with risk factors.Bosnian journal of basic medical sciences · 2010Trial
- The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia.European journal of applied physiology · 2009Trial
- Forearm vascular reactivity and arterial stiffness in asymptomatic adults from the community.Hypertension (Dallas, Tex. : 1979) · 2008Trial
- Sonic vibrational analysis provides continuous measurement of arterial properties.Journal of clinical monitoring and computing · 2000Trial
- Retinal Vessel Flicker Light Responsiveness and Its Relation to Analysis Protocols and Static and Metabolic Data in Healthy Subjects.Biomedicines · 2025Article
- Skeletal Muscle Tissue Saturation Changes Measured Using Near Infrared Spectroscopy During Exercise Are Associated With Post-Occlusive Reactive Hyperaemia.Frontiers in physiology · 2022Article
- Endothelial Progenitor Cells Dysfunctions and Cardiometabolic Disorders: From Mechanisms to Therapeutic Approaches.International journal of molecular sciences · 2021Review
- Kinetic differences between macro- and microvascular measures of reactive hyperemia.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Associations of sex, age and adiposity in endothelium-independent dilation in children.Physiological measurement · 2018Article
- Flow Mediated Dilatation as a Biomarker in Vascular Surgery Research.Journal of atherosclerosis and thrombosis · 2017Review
- Flow Mediated Dilatation and Progression of Abdominal Aortic Aneurysms.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2017Article
- Can a combination of handgrip exercise and prolonged forearm occlusion elicit a maximal brachial artery FMD response?European journal of applied physiology · 2014Article
- Evaluation of endothelial function on atherosclerosis using perfusion index from pulse oximeter.Arquivos brasileiros de cardiologia · 2014Article
- Effect of glucocorticoids on serum lipid profile and endothelial function and arterial wall mechanics.Indian journal of pediatrics · 2013Article
- Combined examination of glyceryl trinitrate-mediated vascular dilation with flow-mediated vascular dilation is essential for assessment of vascular function in type 2 diabetes.Journal of diabetes investigation · 2013Article
- Flow-Mediated Vasodilatation and Intima-Media Thickness in Patients with Coexisting Heart Failure and Diabetes Receiving Medical Therapy.Diagnostics (Basel, Switzerland) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the relation between endothelial dependent and endothelial independent stimuli of varying intensity and measures of vascular function in the brachial artery of young healthy adults, to determine whether these responses are consistent and can be used to assess endothelial function. DESIGN AND
settingHigh resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperaemia induced by forearm cuff occlusion, and after sublingual isosorbide dinitrate (ISDN). Each subject was assigned to a random order of six cuff occlusion times (30 seconds, 1.5, 2.5, 3.5, 4.5, and 8 minutes) and six doses of ISDN (10, 20, 50, 100, 200, and 400 micrograms). SUBJECTS: Three males and three females mean age 31 years (range 25 to 43) with no known risk factors for cardiovascular disease.
main outcome measuresFlow mediated, endothelial dependent dilatation was compared to duration of cuff occlusion, peak reactive hyperaemia, and duration of increased flow. Nitrate induced, endothelial independent dilatation was compared to dose of ISDN and change in flow.
resultsVessel dilatation and duration of peak flow change increased with longer duration of cuff occlusion. After 4.5 minutes of occlusion, flow mediated dilatation was mean (SD) 96 (6)% of maximal response and did not increase significantly with longer occlusion times. No significant dilatation occurred after 10 or 20 micrograms of ISDN in any subject. With increasing doses up to 200 micrograms there was an increase in dilatation. Endothelial independent dilatation did not increase significantly with doses of ISDN above 200 micrograms.
conclusionsMeasures of arterial function vary with duration of blood flow occlusion and ISDN dose. Maximum arterial response was reached in all subjects after 4.5 minutes of blood flow occlusion or 200 micrograms of ISDN. Therefore, these variables produce consistent reproducible measures of endothelial function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.