ArticleAnatomy and embryology1979
Gamma-aminobutyric acid pathways in the cerebellum studied by retrograde and anterograde transport of glutamic acid decarboxylase antibody after in vivo injections.
Article in Anatomy and embryology, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 88 citations in OpenAlex.
- Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice.Frontiers in aging neuroscience · 2021Article
- Toll-Like Receptor 4 Deficiency Impairs Motor Coordination.Frontiers in neuroscience · 2016Article
- Cerebellar Premotor Output Neurons Collateralize to Innervate the Cerebellar Cortex.The Journal of comparative neurology · 2015Article
- Article
- Cerebellar loops: a review of the nucleocortical pathway.Cerebellum (London, England) · 2014Review
- Irisin-immunoreactivity in neural and non-neural cells of the rodent.Neuroscience · 2013Article
- Development and organization of polarity-specific segregation of primary vestibular afferent fibers in mice.Cell and tissue research · 2010Article
- Postnatal expression of GAD67.Neurochemical research · 2010Article
- Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study.Autism research : official journal of the International Society for Autism Research · 2009Article
- Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon.Brain cell biology · 2008Article
- Glutamic acid decarboxylase-positive neuronal cell bodies and terminals in the human cerebellar cortex.The Histochemical journal · 2000Article
- Neurochemical changes in cerebellum of goldfish exposed to various temperatures.Neurochemical research · 1997Article
- The GABAergic cerebello-olivary projection in the rat.Anatomy and embryology · 1991Article
- Topographical organisation within the cerebellar nucleocortical projection to the paravermal cortex of lobule Vb/c in the cat.Experimental brain research · 1990Article
- Somatostatin expression in the cerebellar cortex during postnatal development. An immunohistochemical study in the rat.Anatomy and embryology · 1989Article
- GAD-immunoreactive neural elements in the basilar pontine nuclei and nucleus reticularis tegmenti pontis of the rat. I. Light microscopic studies.Experimental brain research · 1985Article
- Gamma-aminobutyric acid interneurons in the rat hippocampal region studied by retrograde transport of glutamic acid decarboxylase antibody after in vivo injections.Anatomy and embryology · 1983Article
- Chemical heterogeneity in cerebellar Purkinje cells: existence and coexistence of glutamic acid decarboxylase-like and motilin-like immunoreactivities.Proceedings of the National Academy of Sciences of the United States of America · 1981Article
- The total number, time or origin and kinetics of proliferation of neurons comprising the deep cerebellar nuclei in the rhesus monkey.Experimental brain research · 1981Article
- EM-autoradiography of cerebellar nucleocortical terminals in the cat.Anatomy and embryology · 1980Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injections of characterized antibody against glutamic acid decarboxylase (GAD), the enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA), were made into the cerebellum. Small cortical injections of anti-GAD antibody produced labeled stellate, basket, Purkinje, and Golgi cells and their processes at the injection site. Anterograde transport of GAD antigen-antibody complexes in Purkinje cell axons caused intense labelling of terminals in deep cerebellar and several vestibular nuclei. Small groups of mossy fiber rosettes labeled and produced retrograde labeling and GAD immunoreactivity in a small number of pleomorphic neurons in the deep cerebellar nuclei. Injections into the dentate nucleus produced retrograde labeling in Purkinje cell bodies and anterograde label in a small number of mossy fiber rosettes. All projections conformed to previously reported topographic distributions of corticonuclear and nucleocortical cerebellar pathways. These findings confirm the GABA content of most Purkinje cell-deep nuclei connections and provide new evidence for a GABA component in part of the nucleocortical pathway in the cerebellum. Immunocytochemical controls for specificity were conducted by injections of preimmune rabbit serum as a substitute for GAD antibody. Only nonspecific labeling was obtained in these cases. Colchicine caused a cumulative enhancement of GAD immunoreactivity in all cases. The present studies indicate that the method of in vivo antibody injections can be utilized to study chemically specific connections in nervous tissue.
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