ArticleCancer research1997
Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.
Article in Cancer research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Intronic and promoter polymorphisms of hMLH1/hMSH2 and colorectal cancer risk in Heilongjiang Province of China.Journal of cancer research and clinical oncology · 2015Article
- The mismatch repair protein MSH2 is rate limiting for repeat expansion in a fragile X premutation mouse model.Human mutation · 2014Article
- Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.PLoS genetics · 2008Article
- Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes.Current genetics · 2008Review
- The effect of curcumin on mismatch repair (MMR) proteins hMSH2 and hMLH1 after ultraviolet (UV) irradiation on HL-60 cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2003Article
- Article
- Base excision repair of adenine/8-oxoguanine mispairs by an aphidicolin-sensitive DNA polymerase in human cell extracts.Oncogene · 2002Article
- Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents.Oncogene · 2001Article
- Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts.Nucleic acids research · 2001Article
- Mouse mismatch repair gene Msh2 is not essential for transcription-coupled repair of UV-induced cyclobutane pyrimidine dimers.Oncogene · 2001Article
- BRCA1 and cell signaling.Oncogene · 2000Review
- Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA.The Plant cell · 2000Article
- Different mutator phenotypes in Mlh1- versus Pms2-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities.American journal of human genetics · 1999Review
- Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Physical interaction between components of DNA mismatch repair and nucleotide excision repair.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
- Retraction · 2003-07-01Error in Methods · Error in Results and/or Conclusions · Unreliable Results and/or Conclusions · · Steven Anthony Leadon has a finding for misconduct; See also: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259672/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019656/
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- Retracted
Authors and funding
2 authors.
Funding
Abstract
Defects in DNA mismatch repair have been associated with both hereditary and sporadic forms of cancer. Recently, it has been shown that human cell lines deficient in mismatch repair were also defective in the transcription-coupled repair (TCR) of UV-induced DNA damage. We examined whether TCR of ionizing radiation-induced DNA damage also requires the genes involved in DNA mismatch repair. Cells defective in the hMSH2 gene were deficient in the removal of oxidative damage, including thymine glycols, from the transcribed strand of an active gene. However, an hMLH1 mutant showed normal levels of TCR. By comparison, defects in either hMSH2 or hMLH1 resulted in reduced TCR of UV damage. Introducing chromosomes carrying either hMSH2 or hMLH1 into these cell lines restored their ability to carry out TCR. Deficiencies in either hMSH2 or hMLH1 did not result in decreased overall genomic levels of repair or lead to an increased sensitivity to either UV or ionizing radiation. Our results provide the first evidence for a protein that is absolutely required for the preferential removal of UV-induced DNA damage but not oxidative DNA damage from the transcribed strand of an active human gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.