ArticleThe Journal of physiology1997
The biphasic force-velocity relationship in frog muscle fibres and its evaluation in terms of cross-bridge function.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 92 citations in OpenAlex.
- A mechanokinetic actomyosin model predicts different orthophosphate sensitivities of force and ATP turnover rate during isometric muscle contraction.Frontiers in physiology · 2025Article
- Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM.The Journal of general physiology · 2023Article
- Insights into Muscle Contraction Derived from the Effects of Small-Molecular Actomyosin-Modulating Compounds.International journal of molecular sciences · 2022Article
- The effects of inorganic phosphate on muscle force development and energetics: challenges in modelling related to experimental uncertainties.Journal of muscle research and cell motility · 2021Article
- Hypothesis: Single Actomyosin Properties Account for Ensemble Behavior in Active Muscle Shortening and Isometric Contraction.International journal of molecular sciences · 2020Article
- Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers.International journal of molecular sciences · 2019Review
- Nonlinear Actomyosin Elasticity in Muscle?Biophysical journal · 2019Article
- On the Shape of the Force-Velocity Relationship in Skeletal Muscles: The Linear, the Hyperbolic, and the Double-Hyperbolic.Frontiers in physiology · 2019Review
- A new myofilament contraction model with ATP consumption for ventricular cell model.The journal of physiological sciences : JPS · 2018Article
- Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?International journal of molecular sciences · 2018Review
- Actomyosin interaction at low ATP concentrations.European biophysics journal : EBJ · 2017Article
- Actomyosin based contraction: one mechanokinetic model from single molecules to muscle?Journal of muscle research and cell motility · 2016Article
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies.Frontiers in physiology · 2014Article
- Hill's equation of muscle performance and its hidden insight on molecular mechanisms.The Journal of general physiology · 2013Review
- Nonlinear cross-bridge elasticity and post-power-stroke events in fast skeletal muscle actomyosin.Biophysical journal · 2013Article
- A cross-bridge cycle with two tension-generating steps simulates skeletal muscle mechanics.Biophysical journal · 2013Article
- Variation in the determinants of power of chemically skinned type I rat soleus muscle fibres.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Significant impact on muscle mechanics of small nonlinearities in myofilament elasticity.Biophysical journal · 2010Article
- Actomyosin-ADP states, interhead cooperativity, and the force-velocity relation of skeletal muscle.Biophysical journal · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The relationship between force and velocity of shortening was studied during fused tetani of single fibres isolated from the anterior tibialis muscle of Rana temporaria (1.5-3.3 degrees C; sarcomere length, 2.20 microns). Stiffness was measured as the change in force that occurred in response to a 4 kHz length oscillation of the fibre. 2. The results confirmed the existence of two distinct curvatures of the force-velocity relationship located on either side of a breakpoint in the high-force, low-velocity range. Reduction of the isometric force (P0) to 83.4 +/- 1.7% (mean +/- S.E.M., n = 5) of the control value by dantrolene did not affect the relative shape of the force-velocity relationship. The breakpoint between the two curvatures was located at 75.9 +/- 0.9% of P0 and 11.4 +/- 0.6% of maximum velocity of shortening (Vmax) in control Ringer solution and at 75.6 +/- 0.7% of P0 and 12.2 +/- 0.7% of Vmax in the presence of dantrolene. These results provide evidence that the transition between the two curvatures of the force-velocity relationship is primarily related to the speed of shortening, not to the actual force within the fibre. 3. The instantaneous stiffness varied with the speed of shortening forming a biphasic relationship with a breakpoint near 0.15 Vmax and 0.8 P0, respectively. The force/stiffness ratio (probably reflecting the average force per cross-bridge), increased with force during shortening. The increase of the force/stiffness ratio with force was less steep at forces exceeding 0.8 P0 than below this point. 4. A four-state cross-bridge model (described in the Appendix) was used to evaluate the experimental results. The model reproduces with great precision the characteristic features of the force-stiffness-velocity relationships recorded in intact muscle fibres.
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