ArticleThe Journal of physiology1997
Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Therapy development for spinal muscular atrophy: perspectives for muscular dystrophies and neurodegenerative disorders.Neurological research and practice · 2022Review
- BDNF/trkB Induction of Calcium Transients through CaFrontiers in molecular neuroscience · 2017Article
- Synaptic plasticity: the new explanation of visceral hypersensitivity in rats with Trichinella spiralis infection?Digestive diseases and sciences · 2009Article
- Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan.Journal of neurophysiology · 2008Article
- Prenatal opiate exposure impairs radial arm maze performance and reduces levels of BDNF precursor following training.Brain research · 2008Article
- Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms.The Journal of cell biology · 2006Article
- Synaptic targeting of retrogradely transported trophic factors in motoneurons: comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Brain-derived neurotrophic factor modulation of GABAergic synapses by postsynaptic regulation of chloride transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A novel BDNF gene promoter directs expression to skeletal muscle.BMC neuroscience · 2003Article
- Intracellular Ca(2+) and Ca(2+)/calmodulin-dependent kinase II mediate acute potentiation of neurotransmitter release by neurotrophin-3.The Journal of cell biology · 2000Article
- Stabilization of growing retinal axons by the combined signaling of nitric oxide and brain-derived neurotrophic factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Excitatory synaptogenesis between identified Lymnaea neurons requires extrinsic trophic factors and is mediated by receptor tyrosine kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Long-term enhancement of central synaptic transmission by chronic brain-derived neurotrophic factor treatment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Neurotrophin-3 potentiates excitatory GABAergic synaptic transmission in cultured developing hypothalamic neurones of the rat.The Journal of physiology · 1999Article
- Target-dependent regulation of acetylcholine secretion at developing motoneurons in Xenopus cell cultures.The Journal of physiology · 1999Article
- Enhancement of spontaneous transmitter release at neonatal mouse neuromuscular junctions by the glial cell line-derived neurotrophic factor (GDNF).The Journal of physiology · 1998Article
- Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus.Learning & memory (Cold Spring Harbor, N.Y.)Article
- Trophic factor-induced plasticity of synaptic connections between identified Lymnaea neurons.Learning & memory (Cold Spring Harbor, N.Y.)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The ability of different neurotrophic factors to maintain and regulate synaptic function at the developing motoneuron was studied in Xenopus nerve-muscle co-cultures. Spontaneous synaptic currents (SSCs) were measured by using whole-cell voltage-clamped myocytes. 2. Compared with natural synapses, motoneurons without contact on a myocyte (naive neurons) released ACh in smaller quantal packets, the amplitude being inversely proportional to the days in culture. The mean SSC amplitudes of naive neurons, which were measured by manipulating a myoball into contact with the myocyte-free nerve terminals to form a manipulated synapse, were 99.5 +/- 6.7 and 48.2 +/- 1.9 pA for day-1 and day-3 cultures, respectively. 3. Chronic treatment of day-1 cultures with brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), ciliary neurotrophic factor (CNTF) or glial cell line-derived neurotrophic factor (GDNF) for 2 days, increased the ACh quantal size of naive motoneurons in a concentration-dependent manner, whereas insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) had no effect, even at high concentrations. 4. The interaction of various neurotrophic factors was examined, using concentrations that gave maximal effects. Combination of CNTF plus BDNF or CNTF plus NT-3 had synergistic effects in potentiating SSC amplitude of the manipulated synapse of naive neurons, whereas NT-3 plus BDNF, NT-3 plus GDNF, BDNF plus GDNF or CNTF plus GDNF had no synergistic action. 5. Chronic treatment with d-tubocurarine for 2 days resulted in a reduction of the quantal size of natural synapses. Concomitant treatment with BDNF, NT-3, GDNF, CNTF but not bFGF or IGF-1, reconstituted the SSC amplitude. 6. Taken together, these findings suggest that BDNF, NT-3, NT-4, CNTF and GDNF may regulate and maintain the synaptic function of developing motoneurons, and different neurotrophic factors utilizing distinct signalling mechanisms may have synergistic actions.
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