ArticleGenetics1997
Clusters of identical new mutations can account for the "overdispersed" molecular clock.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Pattern of mutation rates in the germline of Drosophila melanogaster males from a large-scale mutation screening experiment.G3 (Bethesda, Md.) · 2014Article
- Adaptation of Drosophila melanogaster to increased NaCl concentration due to dominant beneficial mutations.Genetica · 2011Article
- Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila.Molecular biology and evolution · 2008Article
- Estimating mutation rate: how to count mutations?Genetics · 2003Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germ-cell mutations may occur during meiosis, giving rise to independent mutant gametes in a Poisson process, or before meiosis, giving rise to multiple copies of identical mutant gametes at a much higher probability than the Poisson expectation. We report that the occurrence of these early premeiotic clusters of new identical mutant alleles increases the variance-to-mean ratio of mutation rate (R(u) > 1). This leads to an expected variance-to-mean ratio (R(t)) of the molecular clock that is always greater than one and may cover the observed range of R(t) values. Hence, the molecular clock may not be over-dispersed based on this new mutational model that includes clusters. To get a better estimation of R(u) and R(t), one needs measurements of the intrageneration variation of reproductive success (Nt/Ne(i)), population dynamics (ki), and the proportion of new mutations that occur in clusters (rc), especially those formed before germ-cell differentiation.
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