ArticleGenetics1997
The genes raw and ribbon are required for proper shape of tubular epithelial tissues in Drosophila.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Raw defines a TIR-fold cADPR hydrolase cooperating with dSarm in development and axon degeneration.Cell communication and signaling : CCS · 2026Article
- Ribbon constrains dendritic pruning via actin scaffolding and exocyst complex.Cellular & molecular biology letters · 2026Article
- TheGenes · 2026Article
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.The Journal of cell biology · 2022Article
- The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut.Hereditas · 2020Article
- An RNAi Screen Identifies New Genes Required for Normal Morphogenesis of Larval Chordotonal Organs.G3 (Bethesda, Md.) · 2018Article
- Identification of raw as a regulator of glial development.PloS one · 2018Article
- Genome-wide identification of Drosophila dorso-ventral enhancers by differential histone acetylation analysis.Genome biology · 2016Article
- Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors.PloS one · 2016Article
- Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.Development (Cambridge, England) · 2015Article
- raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis.Developmental biology · 2012Article
- Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin.Development (Cambridge, England) · 2011Article
- Article
- Kinetic and mechanical analysis of live tube morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.Developmental biology · 2008Article
- Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans.Neural development · 2007Article
- From fate to function: the Drosophila trachea and salivary gland as models for tubulogenesis.Differentiation; research in biological diversity · 2006Review
- Identification of genes controlling malpighian tubule and other epithelial morphogenesis in Drosophila melanogaster.Genetics · 1999Article
- Shaping up for action: the path to physiological maturation in the renal tubules of Drosophila.OrganogenesisReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The products of two genes, raw and ribbon (rib), are required for the proper morphogenesis of a variety of tissues. Malpighian tubules mutant for raw or rib are wider and shorter than normal tubules, which are only two cells in circumference when they are fully formed. The mutations alter the shape of the tubules beginning early in their formation and block cell rearrangement late in development, which normally lengthens and narrows the tubes. Mutations of both genes affect a number of other tissues as well. Both genes are required for dorsal closure and retraction of the CNS during embryonic development. In addition, rib mutations block head involution, and broaden and shorten other tubular epithelia (salivary glands, tracheae, and hindgut) in much same manner as they alter the shape of the Malpighian tubules. In tissues in which the shape of cells can be observed readily, rib mutations alter cell shape, which probably causes the change in shape of the organs that are affected. In double mutants raw enhances the phenotypes of all the tissues that are affected by rib but unaffected by raw alone, indicating that raw is also active in these tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.