ArticleGenetics1997
Polymorphism and divergence at a Drosophila pseudogene locus.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Emergence and evolution of chimeric pseudogenes (φgenes) contribute to genetic and functional diversity of the human genome.Nucleic acids research · 2026Article
- TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis.Biochimica et biophysica acta · 2016Review
- The evolution of sperm competition genes: The effect of mating system on levels of genetic variation within and between species.Evolution; international journal of organic evolution · 2016Article
- A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes.PLoS genetics · 2010Article
- Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus.Journal of molecular evolution · 2009Article
- Article
- How intron splicing affects the deletion and insertion profile in Drosophila melanogaster.Genetics · 2002Article
- Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Patterns of genetic variation at a chromosome 4 locus of Drosophila melanogaster and D. simulans.Genetics · 2002Article
- DNA sequence variation and the recombinational landscape in Drosophila pseudoobscura: a study of the second chromosome.Genetics · 1999Article
- Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes.Genetics · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The larval cuticle protein (Lcp) cluster in Drosophila melanogaster contains four functional genes and a closely related pseudogene. A 630-bp fragment including the larval cuticle pseudogene locus (Lcp psi) was nucleotide sequenced in 10 strains of D. melanogaster and a 458-bp Lcp psi fragment from D. simulans was also sequenced. We used these data to test the hypotheses that the rates of synonymous and nonsynonymous substitution are equal, that the absolute levels of variation are higher than in functional genes, and that intraspecific polymorphism is correlated with interspecific divergence. As predicted, synonymous and nonsynonymous substitution rates were equivalent, and overall nucleotide divergence between D. melanogaster and D. simulans (Jukes-Cantor distance = 0.149 +/- 0.150) was extremely high. However, within-species DNA sequence comparisons at Lcp psi revealed lower levels of polymorphism (theta = 0.001 +/- 0.001) than at many functional loci in D. melanogaster. Using the HUDSON, KREITMAN, and AGUADE (HKA) test, we show that the level of polymorphism in Lcp psi within D. melanogaster is lower than expected given the amount of divergence between D. melanogaster and D. simulans when the pseudogene data are compared to the Adh 5' flanking region. Because the Lcp psi lies in a region of relatively infrequent recombination, we suggest that the low level of within-species polymorphism is the result of background selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.