ArticleGenetics1997
Occurrence of repeat induced point mutation in long segmental duplications of Neurospora.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Phylogenomic signatures of repeat-induced point mutations across the fungal kingdom.PLoS biology · 2025Article
- An Anatomy of Fungal Eye: Fungal Photoreceptors and Signalling Mechanisms.Journal of fungi (Basel, Switzerland) · 2023Review
- Transposon-mediated telomere destabilization: a driver of genome evolution in the blast fungus.Nucleic acids research · 2020Article
- Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.Scientific reports · 2015Article
- Neurospora Heterokaryons with Complementary Duplications and Deficiencies in Their Constituent Nuclei Provide an Approach to Identify Nucleus-Limited Genes.G3 (Bethesda, Md.) · 2015Article
- Neurospora crassa, a model system for epigenetics research.Cold Spring Harbor perspectives in biology · 2013Review
- A factor in a wild isolated Neurospora crassa strain enables a chromosome segment duplication to suppress repeat-induced point mutation.Journal of biosciences · 2011Article
- Titration of repeat-induced point mutation (RIP) by chromosome segment duplications in Neurospora crassa.Genetica · 2008Article
- David D. Perkins (1919-2007): a lifetime of Neurospora genetics.Journal of genetics · 2007Article
- Successful beyond expectation: David Perkins's research with chromosome rearrangements in Neurospora.Journal of biosciences · 2007Article
- Collateral damage: spread of repeat-induced point mutation from a duplicated DNA sequence into an adjoining single-copy gene in Neurospora crassa.Journal of biosciences · 2005Article
- VIVID is a flavoprotein and serves as a fungal blue light photoreceptor for photoadaptation.The EMBO journal · 2003Article
- Genetic analysis of wild-isolated Neurospora crassa strains identified as dominant suppressors of repeat-induced point mutation.Genetics · 2003Article
- dim-2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora.The EMBO journal · 2001Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Previous studies of repeat induced point mutation (RIP) have typically involved gene-size duplications resulting from insertion of transforming DNA at ectopic chromosomal positions. To ascertain whether genes in larger duplications are subject to RIP, progeny were examined from crosses heterozygous for long segmental duplications obtained using insertional or quasiterminal translocations. Of 17 distinct mutations from crossing 11 different duplications, 13 mapped within the segment that was duplicated in the parent, one was closely linked, and three were unlinked. Half of the mutations in duplicated segments were at previously unknown loci. The mutations were recessive and were expressed both in haploid and in duplication progeny from Duplication x Normal, suggesting that both copies of the wild-type gene had undergone RIP. Seven transition mutations characteristic of RIP were found in 395 base pairs (bp) examined in one ro-11 allele from these crosses and three were found in approximately 750 bp of another. A single chain-terminating C to T mutation was found in 800 bp of arg-6. RIP is thus responsible. These results are consistent with the idea that the impaired fertility that is characteristic of segmental duplications is due to inactivation by RIP of genes needed for progression through the sexual cycle.
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