ArticleThe Plant cell1997
A gene fusion at a homeobox locus: alterations in leaf shape and implications for morphological evolution.
Article in The Plant cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 207 citations in OpenAlex.
- AtFusionDB: A Comprehensive Database of Fusion Transcripts in Model Plant Arabidopsis thaliana.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- The landscape of fusion transcripts in plants: a new insight into genome complexity.BMC plant biology · 2024Article
- Article
- Leaf form diversity and evolution: a never-ending story in plant biology.Journal of plant research · 2024Review
- Shaping leaves through TALE homeodomain transcription factors.Journal of experimental botany · 2024Review
- The developmental dynamics in cool season legumes with focus on chickpea.Plant molecular biology · 2023Review
- Diversity of tomato leaf form provides novel insights into breeding.Breeding science · 2023Article
- Article
- Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibrium.PLoS genetics · 2021Article
- Simple and Divided Leaves in Ferns: Exploring the Genetic Basis for Leaf Morphology Differences in the GenusInternational journal of molecular sciences · 2020Article
- Genetic control of compound leaf development in the mungbean (Horticulture research · 2019Article
- AtFusionDB: a database of fusion transcripts in Arabidopsis thaliana.Database : the journal of biological databases and curation · 2019Article
- Ectopic expression a tomato KNOX Gene Tkn4 affects the formation and the differentiation of meristems and vasculature.Plant molecular biology · 2015Article
- Identification of phloem-mobile mRNA.Journal of plant research · 2015Review
- Genes involved in floral meristem in tomato exhibit drastically reduced genetic diversity and signature of selection.BMC plant biology · 2014Article
- Regulation of Compound Leaf Development.Plants (Basel, Switzerland) · 2013Review
- A role for APETALA1/fruitfull transcription factors in tomato leaf development.The Plant cell · 2013Article
- Trifoliate encodes an MYB transcription factor that modulates leaf and shoot architecture in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compound leaves are seen in many angiosperm genera and are thought to be either fundamentally different from simple leaves or elaborations of simple leaves. The knotted1-like homeobox (knox) genes are known to regulate plant development. When overexpressed in homologous or heterologous species, this family of genes can cause changes in leaf morphology, including excessive leaf compounding in tomato. We describe here an instance of a spontaneously arisen fusion between a gene encoding a metabolic enzyme and a homeodomain protein. We show that the fusion results in overexpression of the homeodomain protein and a change in morphology that approximates the changes caused by overexpression of the same gene under the control of the cauliflower mosaic virus 35S promoter in transgenic plants. Exon-shuffling events can account for the modularity of proteins. If the shuffled exons are associated with altered promoters, changes in gene expression patterns can result. Our results show that gene fusions of this nature can cause changes in expression patterns that lead to altered morphology. We suggest that such phenomena may have played a role in the evolution of form.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.