ArticleMolecular biology of the cell1997
A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation.
Article in Molecular biology of the cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 97 citations in OpenAlex.
- Genome-wide analysis reveals a switch in the translational program upon oocyte meiotic resumption.Nucleic acids research · 2020Article
- Cyclin B2 is required for progression through meiosis in mouse oocytes.Development (Cambridge, England) · 2019Article
- Female Infertility Caused by Mutations in the Oocyte-Specific Translational Repressor PATL2.American journal of human genetics · 2017Article
- Dueling RNA-binding proteins promote translational activation.Nature structural & molecular biology · 2017Article
- Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs.Nature structural & molecular biology · 2017Article
- Functional Integration of mRNA Translational Control Programs.Biomolecules · 2015Review
- Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2.The Journal of biological chemistry · 2014Article
- Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.PloS one · 2014Article
- An unusual two-step control of CPEB destruction by Pin1.Molecular and cellular biology · 2013Article
- Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation.Molecular reproduction and development · 2012Article
- Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.The Journal of biological chemistry · 2012Article
- Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Punctuated cyclin synthesis drives early embryonic cell cycle oscillations.Molecular biology of the cell · 2012Article
- Biochemical characterization of Pumilio1 and Pumilio2 in Xenopus oocytes.The Journal of biological chemistry · 2011Article
- To polyadenylate or to deadenylate: that is the question.Cell cycle (Georgetown, Tex.) · 2010Review
- Developmental timing of mRNA translation--integration of distinct regulatory elements.Molecular reproduction and development · 2010Review
- Meiosis requires a translational positive loop where CPEB1 ensues its replacement by CPEB4.The EMBO journal · 2010Article
- Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression.The EMBO journal · 2010Article
- Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.Molecular reproduction and development · 2008Article
- A novel mRNA 3' untranslated region translational control sequence regulates Xenopus Wee1 mRNA translation.Developmental biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During oocyte maturation and early development, mRNAs receive poly(A) in the cytoplasm at distinct times relative to one another and to the cell cycle. These cytoplasmic polyadenylation reactions do not occur during oogenesis, but begin during oocyte maturation and continue throughout early development. In this report, we focus on the link between cytoplasmic polyadenylation and control of the cell cycle during meiotic maturation. Activation of maturation promoting factor, a complex of CDK1 and cyclin, is required for maturation and dependent on c-mos protein kinase. We demonstrate here that two classes of polyadenylation exist during oocyte maturation, defined by their dependence of c-mos and CDK1 protein kinases. Polyadenylation of the first class of mRNAs (class I) is independent of c-mos and CDK1 kinase activities, whereas polyadenylation of the second class (class II) requires both of these activities. Class I polyadenylation, through its effects on c-mos mRNA, is required for class II polyadenylation. cis-acting elements responsible for this distinction reside in the 3'-untranslated region, upstream of the polyadenylation signal AAUAAA. Cytoplasmic polyadenylation elements (CPEs) are sufficient to specify class I polyadenylation, and subtle changes in the CPE can substantially, though not entirely, shift an RNA from class I to class II. Activation of class I polyadenylation events is independent of hyperphosphorylation of CPE-binding protein or poly(A) polymerase, and requires cellular protein synthesis. The two classes of polyadenylation and of mRNA define a dependent pathway, in which polyadenylation of certain mRNAs requires the prior polyadenylation of another. We propose that this provides one method of regulating the temporal order of polyadenylation events, and links polyadenylation to the control of the meiotic cell cycle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.