ArticleMolecular biology of the cell1997
A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.
Article in Molecular biology of the cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Proteomic investigation of Cbl and Cbl-b in neuroblastoma cell differentiation highlights roles for SHP-2 and CDK16.iScience · 2021Article
- Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains.Journal of cell science · 2019Article
- SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.The Journal of biological chemistry · 2014Article
- SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Neurite outgrowth of PC12 cells by 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK inhibitor.Neurochemical research · 2013Article
- Neurite Outgrowth in PC12 Cells Stimulated by Components from Dendranthema × grandiflorum cv. "Mottenohoka" Is Enhanced by Suppressing Phosphorylation of p38MAPK.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.The Journal of biological chemistry · 2010Article
- Cardiovascular actions of neurotrophins.Physiological reviews · 2009Review
- The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.The Journal of cell biology · 2007Article
- You can't go home again: transcriptionally driven alteration of cell signaling by NGF.Neurochemical research · 2005Review
- Differentiation of neuroblastoma cell line N1E-115 involves several signaling cascades.Neurochemical research · 2005Article
- SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase.The Journal of cell biology · 2003Article
- Article
- SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons.Developmental biology · 2002Article
- Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.Oncogene · 2001Article
- Neurotrophins: roles in neuronal development and function.Annual review of neuroscience · 2001Review
- Article
- Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.Molecular and cellular biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
SHP-1 and SHP-2 are intracellular protein tyrosine phosphatases containing two adjacent src homology 2 domains that target these phosphatases to cell surface receptor signaling complexes and play a role in receptor signal transduction. In this report the PC12 cell system was used to investigate the potential roles of SHP-1 and SHP-2 in the induction of neuronal differentiation by nerve growth factor (NGF). By using neurite outgrowth as a marker for differentiation, the effects of transfected constructs of SHP-1 and SHP-2 were assessed. Overexpression of a catalytically inactive SHP-2, but not a catalytically inactive SHP-1, blocked NGF-stimulated neurite outgrowth. The mitogen-activated protein kinase (MAPK) signaling cascade is important for the morphological differentiation in PC12 cells, and both SHP-1 and SHP-2 have been implicated to act upstream of MAPK in other receptor signaling systems. A positive role for SHP-2 but not SHP-1 in the activation of MAPK by NGF was demonstrated by introduction of the SHP-2 phosphatase mutants along with hemagglutinin-tagged MAPK. Coexpression studies with the SHP-2 mutant along with mutant forms of MAPK kinase suggested that SHP-2 functions upstream of MAPK kinase and MAPK in NGF-induced neurite outgrowth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.