ArticleThe American journal of pathology1997
Chromosome 8p deletions are associated with invasive tumor growth in urinary bladder cancer.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Copy number variations in primary tumor, serum and lymph node metastasis of bladder cancer patients treated with radical cystectomy.Scientific reports · 2020Article
- Review
- Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai.International journal of cancer · 2014Article
- Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations.Carcinogenesis · 2011Article
- Expression of NRG1 and its receptors in human bladder cancer.British journal of cancer · 2011Article
- Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.Cancer cell · 2007Article
- The prognostic value of circulating plasma DNA level and its allelic imbalance on chromosome 8p in patients with hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2006Article
- HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.Oncogene · 2006Article
- Molecular pathways in bladder cancer.Urological research · 2004Review
- Article
- TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.The American journal of pathology · 2004Article
- High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization.Oncogene · 2004Article
- Allelic imbalance regions on chromosomes 8p, 17p and 19p related to metastasis of hepatocellular carcinoma: comparison between matched primary and metastatic lesions in 22 patients by genome-wide microsatellite analysis.Journal of cancer research and clinical oncology · 2003Article
- Chromosomal aberrations related to metastasis of human solid tumors.World journal of gastroenterology · 2002Review
- Genetic aberrations of c-myc and CCND1 in the development of invasive bladder cancer.British journal of cancer · 2002Article
- FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells.The American journal of pathology · 2002Article
- Loss of heterozygosity on chromosomes 11 and 17 are markers of recurrence in TCC of the bladder.British journal of cancer · 2001Article
- FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Isolation and characterization of the TERE1 gene, a gene down-regulated in transitional cell carcinoma of the bladder.Oncogene · 2001Article
- High-resolution physical map and transcript identification of a prostate cancer deletion interval on 8p22.Genome research · 2000Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Alterations of chromosome 8, including deletions of 8p, occur frequently in many tumors. In this study, fluorescence in situ hybridization was used to study the relationship between 8p deletions, 8q gains, and phenotype in bladder cancer. Cells from 87 tumors were examined by dual-labeling fluorescence in situ hybridization with a centromere 8 probe (pJM12) and P1 probes for 8p22, 8p12, 8q12, and 8q24. Both 8p22 deletions and 8q24 gains were strongly associated with tumor phenotype. There was a marked difference in 8p22 deletions between noninvasive (pTa) tumors (3/33) and minimally invasive (pT1) tumors (8/19; P = 0.005) whereas there was no significant difference between pT1 and muscle-invasive (pT2-4) tumors (19/35; P = 0.3926). Six tumors with 8p22 deletion were examined at 8p12. Three of these tumors showed no 8p12 deletion, narrowing down the site of a putative tumor suppressor gene distal to 8p12. In one other case, there was a marked increase in 8p12 copy number (> 40 per cell; amplification), suggesting the presence of an oncogene involved in bladder cancer at 8p12. The marked difference in 8p22 deletions between noninvasive (pTa) and minimally invasive (pT1) tumors is consistent with a role of a putative tumor suppressor gene on 8p for development of invasive tumor phenotype.
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Registered trials
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