ArticleBiophysical journal1997
Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Model of Calcium Dynamics RegulatingActa biotheoretica · 2024Article
- CaAmerican journal of physiology. Endocrinology and metabolism · 2023Review
- Visualizing hypoxic modulation of beta cell secretions via a sensor augmented oxygen gradient.Microsystems & nanoengineering · 2023Article
- Effects of piperine and deoxyschizandrin on synchronized Ca²⁺ oscillations in cultured hippocampal neuronal cells.European biophysics journal : EBJ · 2013Article
- The impact of mathematical modeling on the understanding of diabetes and related complications.CPT: pharmacometrics & systems pharmacology · 2013Article
- Time-dependent changes in membrane excitability during glucose-induced bursting activity in pancreatic β cells.The Journal of general physiology · 2011Article
- Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study.The Journal of general physiology · 2011Article
- Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.American journal of physiology. Endocrinology and metabolism · 2010Review
- Lessons from models of pancreatic beta cells for engineering glucose-sensing cells.Mathematical biosciences · 2010Review
- A mathematical model of β-cells in an islet of Langerhans sensing a glucose gradient.HFSP journal · 2010Article
- A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.Biophysical journal · 2009Article
- Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretion.Journal of diabetes science and technology · 2009Review
- The electrophysiology of the beta-cell based on single transmembrane protein characteristics.Biophysical journal · 2007Article
- Three roads to islet bursting: emergent oscillations in coupled phantom bursters.Biophysical journal · 2004Article
- A model of phosphofructokinase and glycolytic oscillations in the pancreatic beta-cell.Biophysical journal · 2003Article
- Calcium-activated K+ channels of mouse beta-cells are controlled by both store and cytoplasmic Ca2+: experimental and theoretical studies.The Journal of general physiology · 2002Article
- Modeling of membrane excitability in gonadotropin-releasing hormone-secreting hypothalamic neurons regulated by Ca2+-mobilizing and adenylyl cyclase-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The phantom burster model for pancreatic beta-cells.Biophysical journal · 2000Article
- Dynamical complexity and temporal plasticity in pancreatic beta-cells.Journal of biosciences · 2000Review
- Effect of Na/Ca exchange on plateau fraction and [Ca]i in models for bursting in pancreatic beta-cells.Biophysical journal · 1999Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular calcium concentration has interesting effects on bursting of pancreatic beta-cells. The mechanism underlying the extracellular Ca2+ effect is not well understood. By incorporating a low-threshold transient inward current to the store-operated bursting model of Chay, this paper elucidates the role of the extracellular Ca2+ concentration in influencing electrical activity, intracellular Ca2+ concentration, and the luminal Ca2+ concentration in the intracellular Ca2+ store. The possibility that this inward current is a carbachol-sensitive and TTX-insensitive Na+ current discovered by others is discussed. In addition, this paper explains how these three variables respond when various pharmacological agents are applied to the store-operated model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.