ArticleBiophysical journal1997
Cochlear outer hair cell bending in an external electric field.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- Regulation of cochlear hair cell function by intracellular calcium stores.Frontiers in cellular neuroscience · 2024Article
- TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma.Nature communications · 2023Article
- TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing.JCI insight · 2019Article
- Motile responses of cochlear outer hair cells stimulated with an alternating electrical field.Hearing research · 2011Article
- Investigating outer hair cell motility with a combination of external alternating electrical field stimulation and high-speed image analysis.Journal of visualized experiments : JoVE · 2011Article
- Article
- Fast adaptation and Ca2+ sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Internal shearing within the hearing organ evoked by basilar membrane motion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Action of 2,3-butanedione monoxime on capacitance and electromotility of guinea-pig cochlear outer hair cells.The Journal of physiology · 2001Article
- Water permeability of cochlear outer hair cells: characterization and relationship to electromotility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Two distinct Ca(2+)-dependent signaling pathways regulate the motor output of cochlear outer hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- ATP-Induced Ca(2+) release in cochlear outer hair cells: localization of an inositol triphosphate-gated Ca(2+) store to the base of the sensory hair bundle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- The membrane-based mechanism of cell motility in cochlear outer hair cells.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used a high-resolution motion analysis system to reinvestigate shape changes in isolated guinea pig cochlear outer hair cells (OHCs) evoked by low-frequency (2-3 Hz) external electric stimulation. This phenomenon of electromotility is presumed to result from voltage-dependent structural changes in the lateral plasma membrane of the OHC. In addition to well-known longitudinal movements, OHCs were found to display bending movements when the alternating external electric field gradients were oriented perpendicular to the cylindrical cell body. The peak-to-peak amplitude of the bending movement was found to be as large as 0.7 microm. The specific sulfhydryl reagents, p-chloromercuriphenylsulfonic acid and p-hydroxymercuriphenylsulfonic acid, that suppress electrically evoked longitudinal OHCs movements, also inhibit the bending movements, indicating that these two movements share the same underlying mechanism. The OHC bending is likely to result from an electrical charge separation that produces depolarization of the lateral plasma membrane on one side of the cell and hyperpolarization on the other side. In the cochlea, OHC bending could produce radial distortions in the sensory epithelium and influence the micromechanics of the organ of Corti.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.