ArticleBiophysical journal1997
Permeation through the calcium release channel of cardiac muscle.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Interacting ions in biophysics: real is not ideal.Biophysical journal · 2013Review
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Unitary Ca(2+) current through recombinant type 3 InsP(3) receptor channels under physiological ionic conditions.The Journal of general physiology · 2010Article
- Protein structure and ionic selectivity in calcium channels: selectivity filter size, not shape, matters.Biochimica et biophysica acta · 2009Article
- The anomalous mole fraction effect in calcium channels: a measure of preferential selectivity.Biophysical journal · 2008Article
- Energetics of divalent selectivity in a calcium channel: the ryanodine receptor case study.Biophysical journal · 2008Article
- Model channel ion currents in NaCl-extended simple point charge water solution with applied-field molecular dynamics.Biophysical journal · 2001Article
- A mathematical model of cardiocyte Ca(2+) dynamics with a novel representation of sarcoplasmic reticular Ca(2+) control.Biophysical journal · 2000Article
- Progress and prospects in permeation.The Journal of general physiology · 1999Review
- Selectivity and permeation in calcium release channel of cardiac muscle: alkali metal ions.Biophysical journal · 1999Article
- Kramers' diffusion theory applied to gating kinetics of voltage-dependent ion channels.Biophysical journal · 1999Article
- A lattice relaxation algorithm for three-dimensional Poisson-Nernst-Planck theory with application to ion transport through the gramicidin A channel.Biophysical journal · 1999Article
- Dynamic properties of Na+ ions in models of ion channels: a molecular dynamics study.Biophysical journal · 1998Article
- Regulation of cardiac muscle Ca2+ release channel by sarcoplasmic reticulum lumenal Ca2+.Biophysical journal · 1998Article
- Permeation and gating of an inwardly rectifying potassium channel. Evidence for a variable energy well.The Journal of general physiology · 1998Article
- Ion permeation and glutamate residues linked by Poisson-Nernst-Planck theory in L-type calcium channels.Biophysical journal · 1998Article
- Anomalous mole fraction effect, electrostatics, and binding in ionic channels.Biophysical journal · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Current voltage (I-V) relations were measured from the calcium release channel (CRC) of the sarcoplasmic reticulum of cardiac muscle in 12 KCl solutions, symmetrical and asymmetrical, from 25 mM to 2 M. I-V curves are nearly linear, in the voltage range +/- 150 mV approximately 12kT/e, even in asymmetrical solutions, e.g., 2 M // 100 mM. It is awkward to describe straight lines as sums of exponentials in a wide range of solutions and potentials, and so traditional barrier models have difficulty fitting this data. Diffusion theories with constant fields predict curvilinear I-V relations, and so they are also unsatisfactory. The Poisson and Nernst-Planck equations (PNP) form a diffusion theory with variable fields. They fit the data by using adjustable parameters for the diffusion constant of each ion and for the effective density of fixed (i.e., permanent) charge P(x) along the channel's "filter" (7-A diameter, 10 A long). If P(x) is described by just one parameter, independent of x (i.e., P(x) = P0 = -4.2 M), the fits are satisfactory (RMS error/RMS current = 6.4/67), and the estimates of diffusion coefficients are reasonable D(K) = 1.3 x 10(-6) cm2/s, D(Cl) = 3.9 x 10(-6) cm2/s. The CRC seems to have a small selectivity filter with a very high density of permanent charge. This may be a design principle of channels specialized for large flux. The Appendix derives barrier models, and their prefactor, from diffusion theories (with variable fields) and argues that barrier models are poor descriptions of CRCs in particular and open channels in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.