ArticleBiophysical journal1997
Endogenous buffers limit the spread of free calcium in hair cells.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Nimodipine in otolaryngology: from past evidence to clinical perspectives.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2015Review
- Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effects of strontium on the permeation and gating phenotype of calcium channels in hair cells.Journal of neurophysiology · 2008Article
- Determining calcium concentration in heterogeneous model systems using multiple indicators.Cell calcium · 2007Article
- Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice.Journal of the Association for Research in Otolaryngology : JARO · 2004Article
- The distribution of calcium buffering proteins in the turtle cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Effects of permeant ion concentrations on the gating of L-type Ca2+ channels in hair cells.Biophysical journal · 2003Article
- Ca2+ transport properties and determinants of anomalous mole fraction effects of single voltage-gated Ca2+ channels in hair cells from bullfrog saccule.The Journal of physiology · 2002Article
- Development and dissipation of Ca(2+) gradients in adrenal chromaffin cells.Biophysical journal · 2000Article
- Calcium imaging demonstrates colocalization of calcium influx and extrusion in fly photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Tonotopic variations of calcium signalling in turtle auditory hair cells.The Journal of physiology · 2000Article
- Numerical simulation of Ca2+ "sparks" in skeletal muscle.Biophysical journal · 1999Article
- Does Ca2+ reach millimolar concentrations after single photon absorption in Drosophila photoreceptor microvilli?Biophysical journal · 1999Article
- Measurement of action potential-induced presynaptic calcium domains at a cultured neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- ATP-Induced Ca(2+) release in cochlear outer hair cells: localization of an inositol triphosphate-gated Ca(2+) store to the base of the sensory hair bundle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Diffusion barriers limit the effect of mobile calcium buffers on exocytosis of large dense cored vesicles.Biophysical journal · 1999Article
- The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Regulation of free Ca2+ concentration in hair-cell stereocilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mobile Ca2+ buffers in hair cells have been postulated to play a dual role. On one hand, they carry incoming Ca2+ away from synaptic areas, allowing synapses to be rapidly reset. On the other hand, they limit the spread of free Ca2+ into the cell, preventing cross-talk between different pathways that employ Ca2+ as a second messenger. We have obtained evidence for such mobile Ca2+ buffers in hair cells by comparing the patterns of Ca2+-induced fluo-3 fluorescence under whole-cell and perforated-patch recording conditions. Fluorescent signals under perforated-patch conditions are relatively weak and are limited to the immediate vicinity of the membrane. These observations can be explained by a diffusion-reaction scheme that, in addition to Ca2+ and fluo-3, incorporates endogenous fixed and mobile Ca2+ buffers. Our experiments also suggest that the mobility of the endogenous buffer might be higher than previously thought. A high buffer mobility is expected to enhance the cell's ability to rapidly modulate transmitter release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.