ArticleInfection and immunity1997
Neutrophils play a critical role in early resistance to amebic liver abscesses in severe combined immunodeficient mice.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- The emerging role of neutrophilic extracellular traps in intestinal disease.Gut pathogens · 2022Review
- Gasdermins in Innate Host Defense AgainstFrontiers in immunology · 2022Review
- Mechanisms of natural resistance of Balb/c mice to experimental liver amoebiasis.Bioscience reports · 2019Article
- Primary pulmonary amebic abscess in a patient with pulmonary adenocarcinoma: a case report.Infectious diseases of poverty · 2018Article
- Article
- Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis.PLoS pathogens · 2017Article
- Article
- Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors.Cellular and molecular life sciences : CMLS · 2016Review
- A review of the proposed role of neutrophils in rodent amebic liver abscess models.Parasite (Paris, France) · 2016Review
- Entamoeba histolytica Trophozoites and Lipopeptidophosphoglycan Trigger Human Neutrophil Extracellular Traps.PloS one · 2016Article
- On the computational modeling of the innate immune system.BMC bioinformatics · 2013Article
- TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.PLoS pathogens · 2013Article
- The dynamic interdependence of amebiasis, innate immunity, and undernutrition.Seminars in immunopathology · 2012Review
- Computational modeling of microabscess formation.Computational and mathematical methods in medicine · 2012Article
- Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA.Infection and immunity · 2008Article
- Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.Current opinion in immunology · 2007Review
- Resistance to intestinal Entamoeba histolytica infection is conferred by innate immunity and Gr-1+ cells.Infection and immunity · 2005Article
- Ultrastructural observation of human neutrophils during apoptotic cell death triggered by Entamoeba histolytica.The Korean journal of parasitology · 2004Article
- Fate of Entamoeba histolytica during establishment of amoebic liver abscess analyzed by quantitative radioimaging and histology.Infection and immunity · 2002Article
- Shigella infection in a SCID mouse-human intestinal xenograft model: role for neutrophils in containing bacterial dissemination in human intestine.Infection and immunity · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Animal models of liver abscess formation with Entamoeba histolytica suggest that the neutrophil is the first cell of the host immune system to interact with the invading ameba. In vitro studies have suggested that lysis of neutrophils by virulent amebae may exacerbate the damage seen in amebic liver abscesses. To investigate the role of neutrophils in vivo, we used the severe combined immunodeficient (SCID) mouse model of amebic liver abscess formation and compared liver damage in neutrophil-depleted and control mice. We found that neutrophil-depleted animals have significantly larger amebic liver abscesses at early stages of infection and that abscesses in neutrophil-depleted SCID mice lack the prominent inflammatory cell ring seen in amebic liver abscesses in control SCID mice. These data suggest that neutrophils play a protective role in the early host response to amebic infection of the liver.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.