ArticleInfection and immunity1997
Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- Neurodevelopmental impairment associated with neonatal invasive group BBrain, behavior, & immunity - health · 2024Article
- Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro.International journal of molecular sciences · 2020Article
- Article
- Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.Frontiers in pediatrics · 2018Review
- Group B Streptococci Induce Proinflammatory Responses via a Protein Kinase D1-Dependent Pathway.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Neonatal Group B Streptococcal Disease in Otherwise Healthy Infants: Failure of Specific Neonatal Immune Responses.Frontiers in immunology · 2017Article
- Natural Killer Cell Functions during the Innate Immune Response to Pathogenic Streptococci.Frontiers in microbiology · 2017Article
- Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection.PloS one · 2016Article
- Group B Streptococcus Induces a Robust IFN-γ Response by CD4(+) T Cells in an In Vitro and In Vivo Model.Journal of immunology research · 2016Article
- Essential role of interleukin-1 signaling in host defenses against group B streptococcus.mBio · 2014Article
- Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis.Infection and immunity · 2013Article
- Activation of the NLRP3 inflammasome by group B streptococci.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach.BMC genomics · 2011Article
- Induction and termination of inflammatory signaling in group B streptococcal sepsis.Immunological reviews · 2008Review
- Recent advances in understanding the molecular basis of group B Streptococcus virulence.Expert reviews in molecular medicine · 2008Review
- Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells.The Journal of experimental medicine · 2007Article
- Interleukin-18 is an essential element in host resistance to experimental group B streptococcal disease in neonates.Infection and immunity · 2004Article
- Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans.Infection and immunity · 2003Article
- Intracellular and extracellular cytokine production by human mixed mononuclear cells in response to group B streptococci.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines are suspected to play an important role in systemic infections by group B streptococci (GBS), an important cause of neonatal sepsis. This work was undertaken to determine if interleukin 12 (IL-12) is produced in mouse pups infected with GBS and has a role in this sepsis model. IL-12 elevations were measured by both an enzyme-linked immunosorbent assay and a bioassay in plasma samples obtained from 12 to 72 h after GBS challenge. Pretreatment with neutralizing anti-IL-12 antibodies significantly increased lethality and blood CFU (P < 0.05). Conversely, either prophylactically or therapeutically administered recombinant IL-12 (rIL-12) significantly improved survival time and decreased blood CFU. Since these beneficial effects were associated with increased spleen gamma interferon (IFN-gamma) production, we examined whether the latter cytokine mediated the observed rIL-12 effects. Pretreatment with neutralizing anti-IFN-gamma monoclonal antibodies significantly counteracted the beneficial effects of rIL-12 on lethality. Our data indicate that rIL-12 is a possible candidate for treatment of GBS sepsis and that its activities in this model are at least partially mediated by IFN-gamma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.