ArticleThe Journal of physiology1997
Distribution of sarcomere length and intracellular calcium in mouse skeletal muscle following stretch-induced injury.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02125643 (The Underlying Mechanisms From Exercise-induced Muscle Damage on Force Loss), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Underlying Mechanisms From Exercise-induced Muscle Damage on Force Loss
Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- Effects of eccentric exercise-induced muscle damage on intramyocellular lipid concentration and high energy phosphates.European journal of applied physiology · 2010Trial
- Length-dependent changes in voluntary activation, maximum voluntary torque and twitch responses after eccentric damage in humans.The Journal of physiology · 2006Trial
- A comprehensive review of computational and image analysis techniques for quantitative evaluation of striated muscle tissue architecture.Biophysics reviews · 2022Review
- Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs.PLoS computational biology · 2020Article
- l-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain.Physiological reports · 2018Article
- Article
- Human skeletal muscle plasmalemma alters its structure to change its CaNature communications · 2017Article
- The Acute Effect of Local Vibration As a Recovery Modality from Exercise-Induced Increased Muscle Stiffness.Journal of sports science & medicine · 2016Article
- Acute effects of contract-relax (CR) stretch versus a modified CR technique.European journal of applied physiology · 2016Article
- Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance.Journal of inflammation research · 2016Review
- Muscle injury induced by different types of contractions in dystrophic mdx mice.Journal of muscle research and cell motility · 2012Article
- Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury.Histochemistry and cell biology · 2008Article
- Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes.The Journal of physiology · 2005Review
- Maximal force, voluntary activation and muscle soreness after eccentric damage to human elbow flexor muscles.The Journal of physiology · 2005Article
- Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse.The Journal of physiology · 2005Article
- Use of nonsteroidal anti-inflammatory drugs following exercise-induced muscle injury.Sports medicine (Auckland, N.Z.) · 2003Review
- Development of T-tubular vacuoles in eccentrically damaged mouse muscle fibres.The Journal of physiology · 2002Article
- Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications.The Journal of physiology · 2001Review
- The use of the indicator fluo-5N to measure sarcoplasmic reticulum calcium in single muscle fibres of the cane toad.The Journal of physiology · 2001Article
- Changes in passive tension of muscle in humans and animals after eccentric exercise.The Journal of physiology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effect on sarcomere organization of stretching intact single skeletal muscle fibres by 50% of their optimum length (Lo) during ten consecutive short tetani was investigated. Stretch reduced tetanic force to 36 +/- 4% of the pre-stretch condition. Sarcomere organization was analysed using both electron and confocal microscopy. For confocal microscopy the striation pattern was examined by fluorescently staining F-actin with rhodamine-phalloidin. 2. Electron microscopy revealed that fibres which had been stretched during contraction contained areas of severe sarcomere disorganization, as well as adjacent sarcomeres of normal appearance. 3. Confocal images of stretched fibres, which had been fixed and stained with rhodamine-phalloidin, showed focal regions of overstretched sarcomeres and regions where sarcomeres of adjacent myofibrils were out of alignment with each other. Analysis of all sarcomeres along the length of fibres showed regions of sarcomere inhomogeneity were distributed throughout the fibre length and cross-section. 4. Fibres were microinjected with the fluorescent [Ca2+]i indicator fura-2 before being stretched. Conventional wide-field fluorescence imaging microscopy showed that the tetanic [Ca2+]i was reduced after stretching but remained uniformly distributed. 5. This study confirms the finding that stretch-induced muscle injury has components caused by disorganization of the myofibrillar array and by failure of tetanic Ca2+ release. The structural damage is spatially heterogeneous whereas the changes in Ca2+ release appear to be spatially homogeneous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.