ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Selective expression of insulin-like growth factor II in the songbird brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 56 citations in OpenAlex.
- Cell type specializations of the vocal-motor cortex in songbirds.Cell reports · 2023Article
- The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Nervous System.Biochemistry insights · 2019Review
- The insulin-like growth factor 2 gene and locus in nonmammalian vertebrates: Organizational simplicity with duplication but limited divergence in fish.The Journal of biological chemistry · 2018Article
- Article
- Long-distance retinoid signaling in the zebra finch brain.PloS one · 2014Article
- A crayfish insulin-like-binding protein: another piece in the androgenic gland insulin-like hormone puzzle is revealed.The Journal of biological chemistry · 2013Article
- Radioactive in situ hybridization for detecting diverse gene expression patterns in tissue.Journal of visualized experiments : JoVE · 2012Article
- Wandering neuronal migration in the postnatal vertebrate forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Noradrenergic control of gene expression and long-term neuronal adaptation evoked by learned vocalizations in songbirds.PloS one · 2012Article
- Developmental changes in the sexually dimorphic expression of secretory carrier membrane protein 1 and its co-localisation with androgen receptor protein in the zebra finch song system.Journal of neuroendocrinology · 2011Article
- Genes and vocal learning.Brain and language · 2010Review
- Synapsins are late activity-induced genes regulated by birdsong.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Article
- Enriched expression and developmental regulation of the middle-weight neurofilament (NF-M) gene in song control nuclei of the zebra finch.The Journal of comparative neurology · 2007Article
- Differential expression of glutamate receptors in avian neural pathways for learned vocalization.The Journal of comparative neurology · 2004Article
- FoxP2 expression in avian vocal learners and non-learners.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Cell death in the nervous system: lessons from insulin and insulin-like growth factors.Molecular neurobiology · 2003Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuronal replacement occurs in the forebrain of juvenile and adult songbirds. To address the molecular processes that govern this replacement, we cloned the zebra finch insulin-like growth factor II (IGF-II) cDNA, a factor known to regulate neuronal development and survival in other systems, and examined its expression pattern by in situ hybridization and immunocytochemistry in juvenile and adult songbird brains. The highest levels of IGF-II mRNA expression occurred in three nuclei of the song system: in the high vocal center (HVC), in the medial magnocellular nucleus of the neostriatum (mMAN), which projects to HVC, and to a lesser extent in the robust nucleus of the archistriatum (RA), which receives projections from HVC. IGF-II mRNA expression was developmentally regulated in zebra finches. In canary HVC, monthly changes in IGF-II mRNA expression covaried with previously reported monthly differences in neuron incorporation. Combining retrograde tracers with in situ hybridization and immunocytochemistry, we determined that the HVC neurons that project to area X synthesize the IGF-II mRNA, whereas the adjacent RA-projecting neurons accumulate the IGF-II peptide. Our findings raise the possibility that within HVC IGF-II acts as a paracrine signal between nonreplaceable area X-projecting neurons and replaceable RA-projecting neurons, a mode of action that is compatible with the involvement of IGF-II with the replacement of neurons. Additional roles for IGF-II expression in songbird brain are likely, because expression also occurs in some brain areas outside the song system, among them the cerebellar Purkinje cells in which neurogenesis is not known to occur.
Indexed as
Identifiers
9278533PMC6573279W2116286046What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.