ArticleNucleic acids research1997
Binding of NF1 to the MMTV promoter in nucleosomes: influence of rotational phasing, translational positioning and histone H1.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Molecular Mechanism of Nucleosome Recognition by the Pioneer Transcription Factor Sox.Journal of chemical information and modeling · 2023Article
- Chromatin architecture defines the glucocorticoid response.Molecular and cellular endocrinology · 2013Review
- Nuclear Factor I genomic binding associates with chromatin boundaries.BMC genomics · 2013Article
- Binding of nucleoid-associated protein fis to DNA is regulated by DNA breathing dynamics.PLoS computational biology · 2013Article
- Binding of NF-κB to nucleosomes: effect of translational positioning, nucleosome remodeling and linker histone H1.PLoS genetics · 2013Article
- Article
- Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin.Molecular endocrinology (Baltimore, Md.) · 2010Review
- Genome3D: a viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional genome.BMC bioinformatics · 2010Article
- Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elements.The Journal of biological chemistry · 2010Article
- Erk signaling and chromatin remodeling in MMTV promoter activation by progestins.Nuclear receptor signaling · 2009Review
- Multiple sequence-directed possibilities provide a pool of nucleosome position choices in different states of activity of a gene.Epigenetics & chromatin · 2009Article
- MAP kinase-mediated c-fos regulation relies on a histone acetylation relay switch.Molecular cell · 2008Article
- Analysis of chromatin structure in the control regions of the chlamydomonas HSP70A and RBCS2 genes.Plant molecular biology · 2005Article
- Structural requirements of the glucocorticoid-response unit of the carbamoyl-phosphate synthase gene.The Biochemical journal · 2004Article
- Chromatin-mediated restriction of nuclear factor 1/CTF binding in a repressed and hormone-activated promoter in vivo.Molecular and cellular biology · 2004Article
- Histone H1 enhances synergistic activation of the MMTV promoter in chromatin.The EMBO journal · 2003Article
- Enhancer activity of HS2 of the human beta-LCR is modulated by distance from the key nucleosome.Nucleic acids research · 2001Article
- Assembly of MMTV promoter minichromosomes with positioned nucleosomes precludes NF1 access but not restriction enzyme cleavage.Nucleic acids research · 1998Article
- More help than hindrance: nucleosomes aid transcriptional regulation.Nucleus (Austin, Tex.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To analyse the role of rotational orientation and translational positioning of nucleosomal DNA on transcription factor binding we have generated a series of mutant MMTV promoters containing insertions of various lengths between the hormone-responsive region and the binding site for NF1. These various MMTV promoter fragments were assembled in mononucleosomes and used for structural studies and binding experiments. We show that the insertions change the rotational phase and translational positioning of the NF1 site as predicted if the sequences upstream of the insertion site were the main determinants of nucleosome phasing. In band shift experiments with recombinant NF1 we cannot detect binding of the protein to NF1 sites included within the limits of a nucleosome, independent of their rotational orientation. Moving the NF1 site closer to the nucleosome border also did not permit NF1 binding. This behaviour probably reflects the way NF1 binds DNA, namely it almost completely surrounds the circumference of the double helix establishing a large number of contacts with the bases and the backbone. In contrast to the wild-type and short insertion mutants, NF1 bound readily to nucleosomes containing 30 or 50 bp insertions which placed the NF1 site at the nucleosome edge or within linker DNA. NF1 binding to the linker DNA was unaffected by incorporation of histone H1 into the nucleosome particle. These findings are discussed in relation to chromatin remodelling initiated by steroid hormones during induction of the MMTV promoter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.