ArticleNucleic acids research1997
Glucose represses the lactose-galactose regulon in Kluyveromyces lactis through a SNF1 and MIG1- dependent pathway that modulates galactokinase (GAL1) gene expression.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Zinc Finger Protein LipR Represses Docosahexaenoic Acid and Lipid Biosynthesis inApplied and environmental microbiology · 2022Article
- Efficient brazzein production in yeast (Kluyveromyces lactis) using a chemically defined medium.Bioprocess and biosystems engineering · 2021Article
- Kinetics and regulation of lactose transport and metabolism in Kluyveromyces lactis JA6.World journal of microbiology & biotechnology · 2014Article
- Carbon source dependent promoters in yeasts.Microbial cell factories · 2014Review
- Regulations of sugar transporters: insights from yeast.Current genetics · 2013Review
- Characterizing the memory of the GAL regulatory network in Saccharomyces cerevisiae.Systems and synthetic biology · 2011Article
- Dynamic analysis of the KlGAL regulatory system in Kluyveromyces lactis: a comparative study with Saccharomyces cerevisiae.Systems and synthetic biology · 2011Article
- SNF1/AMPK pathways in yeast.Frontiers in bioscience : a journal and virtual library · 2008Review
- Transcriptional rewiring of fungal galactose-metabolism circuitry.Current biology : CB · 2007Article
- Increased glycolytic flux as an outcome of whole-genome duplication in yeast.Molecular systems biology · 2007Article
- Transcriptomic analysis of extensive changes in metabolic regulation in Kluyveromyces lactis strains.Eukaryotic cell · 2006Article
- Role of Snf1p in regulation of intracellular sorting of the lactose and galactose transporter Lac12p in Kluyveromyces lactis.Eukaryotic cell · 2005Article
- Improved production of heterologous proteins by a glucose repression-defective mutant of Kluyveromyces lactis.Applied and environmental microbiology · 2004Article
- Isolation of the MIG1 gene from Candida albicans and effects of its disruption on catabolite repression.Journal of bacteriology · 2000Article
- Yeast carbon catabolite repression.Microbiology and molecular biology reviews : MMBR · 1998Review
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2 authors.
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Abstract
Expression of the lactose-galactose regulon in Kluyveromyces lactis is induced by lactose or galactose and repressed by glucose. Some components of the induction and glucose repression pathways have been identified but many remain unknown. We examined the role of the SNF1 (KlSNF1) and MIG1 (KlMIG1) genes in the induction and repression pathways. Our data show that full induction of the regulon requires SNF1; partial induction occurs in a Klsnf1 -deleted strain, indicating that a KlSNF1 -independent pathway(s) also regulates induction. MIG1 is required for full glucose repression of the regulon, but there must be a KlMIG1 -independent repression pathway also. The KlMig1 protein appears to act downstream of the KlSnf1 protein in the glucose repression pathway. Most importantly, the KlSnf1-KIMig repression pathway operates by modulating KlGAL1 expression. Regulating KlGAL1 expression in this manner enables the cell to switch the regulon off in the presence of glucose. Overall, our data show that, while the Snf1 and Mig1 proteins play similar roles in regulating the galactose regulon in Saccharomyces cerevisiae and K.lactis , the way in which these proteins are integrated into the regulatory circuits are unique to each regulon, as is the degree to which each regulon is controlled by the two proteins.
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