ArticleThe Journal of clinical investigation1997
Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 97 citations in OpenAlex.
- Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism.Nature reviews. Endocrinology · 2024Review
- The βAdvances in pharmacological and pharmaceutical sciences · 2024Review
- β-Adrenergic Signal and Epigenomic Regulatory Process for Adaptive Thermogenesis.Advances in experimental medicine and biology · 2024Review
- Is the βBiomolecules · 2023Review
- GPCR in Adipose Tissue Function-Focus on Lipolysis.Biomedicines · 2023Review
- Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediatedWorld journal of diabetes · 2020Article
- Identification and characterization of adipose surface epitopes.The Biochemical journal · 2020Review
- Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity.The Journal of biological chemistry · 2020Review
- Adrenoceptors in white, brown, and brite adipocytes.British journal of pharmacology · 2019Review
- Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse.The Journal of endocrinology · 2016Article
- JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.Nature communications · 2015Article
- SNP variation in ADRB3 gene reflects the breed difference of sheep populations.Molecular biology reports · 2012Article
- Polymorphism of the bovine ADRB3 gene.Molecular biology reports · 2010Article
- Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism.Endocrine · 2009Article
- Genetically changed mice with chronic deficiency or overexpression of the beta-adrenoceptors--what can we learn for the therapy of heart failure?Pflugers Archiv : European journal of physiology · 2008Review
- Increased Ca2+ sensitivity and protein expression of SERCA 2a in situations of chronic beta3-adrenoceptor deficiency.Pflugers Archiv : European journal of physiology · 2007Article
- beta-Blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene.The pharmacogenomics journal · 2005Article
- Old and new determinants in the regulation of energy expenditure.Journal of endocrinological investigation · 2002Review
- beta(1)-Adrenoceptors compensate for beta(3)-adrenoceptors in ileum from beta(3)-adrenoceptor knock-out mice.British journal of pharmacology · 2001Article
- Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice.British journal of pharmacology · 2000Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeted disruption of mouse beta3-adrenoceptor was generated by homologous recombination, and validated by an acute in vivo study showing a complete lack of effect of the beta3-adrenoceptor agonist CL 316,243 on the metabolic rate of homozygous null (-/-) mice. In brown adipose tissue, beta3-adrenoceptor disruption induced a 66% decrease (P < 0.005) in beta1-adrenoceptor mRNA level, whereas leptin mRNA remained unchanged. Chronic energy balance studies in chow-fed mice showed that in -/- mice, body fat accumulation was favored (+41%, P < 0.01), with a slight increase in food intake (+6%, NS). These effects were accentuated by high fat feeding: -/- mice showed increased total body fat (+56%, P < 0.025) and food intake (+12%, P < 0.01), and a decrease in the fat-free dry mass (-10%, P < 0.05), which reflects a reduction in body protein content. Circulating leptin levels were not different in -/- and control mice regardless of diet. The significant shift to the right in the positive correlation between circulating leptin and percentage of body fat in high fat-fed -/- mice suggests that the threshold of body fat content inducing leptin secretion is higher in -/- than in control mice. Taken together, these studies demonstrate that beta3-adrenoceptor disruption creates conditions which predispose to the development of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.