ArticleProceedings of the National Academy of Sciences of the United States of America1997
Complementation of sporulation and motility defects in a prokaryote by a eukaryotic GTPase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility.PLoS biology · 2019Article
- Engineering Pseudochelin Production in Myxococcus xanthus.Applied and environmental microbiology · 2018Article
- Chemosensory signaling controls motility and subcellular polarity in Myxococcus xanthus.Current opinion in microbiology · 2012Review
- Uncovering the mystery of gliding motility in the myxobacteria.Annual review of genetics · 2011Review
- Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus.BMC microbiology · 2010Article
- Cell polarity/motility in bacteria: closer to eukaryotes than expected?The EMBO journal · 2010Article
- Gliding motility revisited: how do the myxobacteria move without flagella?Microbiology and molecular biology reviews : MMBR · 2010Review
- Localization of MglA, an essential gliding motility protein in Myxococcus xanthus.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Bacterial motility complexes require the actin-like protein, MreB and the Ras homologue, MglA.The EMBO journal · 2010Article
- Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.Current opinion in microbiology · 2009Review
- Periodic reversal of direction allows Myxobacteria to swarm.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Coupling of protein localization and cell movements by a dynamically localized response regulator in Myxococcus xanthus.The EMBO journal · 2007Article
- Triple mutants uncover three new genes required for social motility in Myxococcus xanthus.Genetics · 2007Article
- Expression of yeast mitochondrial aconitase in Bacillus subtilis.Journal of bacteriology · 2006Article
- The orphan response regulator DigR is required for synthesis of extracellular matrix fibrils in Myxococcus xanthus.Journal of bacteriology · 2006Article
- Transposon insertions of magellan-4 that impair social gliding motility in Myxococcus xanthus.Genetics · 2006Article
- Prokaryotic development: emerging insights.Journal of bacteriology · 2003Review
- Mapping of Myxococcus xanthus social motility dsp mutations to the dif genes.Journal of bacteriology · 2002Article
- Myxococcus xanthus mokA encodes a histidine kinase-response regulator hybrid sensor required for development and osmotic tolerance.Journal of bacteriology · 2001Article
- Gliding motility in bacteria: insights from studies of Myxococcus xanthus.Microbiology and molecular biology reviews : MMBR · 1999Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The complex prokaryote, Myxococcus xanthus, undergoes a program of multicellular development when starved for nutrients, culminating in sporulation. M. xanthus makes MglA, a 22-kDa, soluble protein that is required for both multicellular development and gliding motility. MglA is similar in sequence to the Saccharomyces cerevisiae SAR1 protein, a member of the Ras/Rab/Rho superfamily of small eukaryotic GTPases. The SAR1 gene, when integrated into the M. xanthus genome, complements the sporulation defect of a DeltamglA strain. A forward, second-site mutation on the M. xanthus chromosome, rpm, in combination with SAR1, restores fruiting body morphogenesis and gliding motility to a DeltamglA strain. The result that the rpm mutation suppresses the substitution of SAR1 for mglA suggests that Sar1p interacts with other M. xanthus proteins to control the motility-dependent aggregation of cells during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.