ArticleProceedings of the National Academy of Sciences of the United States of America1997
Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 80 citations in OpenAlex.
- Molluscum Contagiosum Virus: Biology and Immune Response.Advances in experimental medicine and biology · 2024Review
- Development of Novel Promiscuous Anti-Chemokine Peptibodies for Treating Autoimmunity and Inflammation.Frontiers in immunology · 2017Article
- Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions.British journal of pharmacology · 2012Article
- Article
- A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities.Journal of virology · 2007Article
- Viral hijacking of G-protein-coupled-receptor signalling networks.Nature reviews. Molecular cell biology · 2004Review
- Viral mimicry of cytokines, chemokines and their receptors.Nature reviews. Immunology · 2003Review
- Correspondence of the functional epitopes of poxvirus and human interleukin-18-binding proteins.Journal of virology · 2001Article
- Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection.Journal of virology · 2001Article
- Viral exploitation and subversion of the immune system through chemokine mimicry.Nature immunology · 2001Review
- Chemokines and viral diseases of the central nervous system.Advances in virus research · 2001Review
- Gene transfer of virally encoded chemokine antagonists vMIP-II and MC148 prolongs cardiac allograft survival and inhibits donor-specific immunity.Gene therapy · 2000Article
- A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum.The Journal of experimental medicine · 2000Article
- Poxvirus homologues of cellular genes.Virus genes · 2000Review
- The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor.Journal of virology · 1999Article
- IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cytomegalovirus-encoded beta chemokine promotes monocyte-associated viremia in the host.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cytomegalovirus encodes a potent alpha chemokine.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The murine cytomegalovirus chemokine homolog, m131/129, is a determinant of viral pathogenicity.Journal of virology · 1999Article
- Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.Infection and immunity · 1998Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Many viruses have evolved mechanisms for evading the host immune system by synthesizing proteins that interfere with the normal immune response. The poxviruses are among the most accomplished at deceiving their hosts' immune systems. The nucleotide sequence of the genome of the human cutaneous poxvirus, molluscum contagiosum virus (MCV) type 1, was recently reported to contain a region that resembles a human chemokine. We have cloned and expressed the chemokine-like genes from MCV type 1 and the closely related MCV type 2 to determine a potential role for these proteins in the viral life cycle. In monocyte chemotaxis assays, the viral proteins have no chemotactic activity but both viral proteins block the chemotactic response to the human chemokine, macrophage inflammatory protein (MIP)-1alpha. Like MIP-1alpha, both viral proteins also inhibit the growth of human hematopoietic progenitor cells, but the viral proteins are more potent in this activity than the human chemokine. These viral chemokines antagonize the chemotactic activity of human chemokines and have an inhibitory effect on human hematopoietic progenitor cells. We hypothesize that the inhibition of chemotaxis is an immune evasion function of these proteins during molluscum contagiosum virus infection. The significance of hematopoietic progenitor cell inhibition in viral pathogenesis is uncertain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.