ArticleProceedings of the National Academy of Sciences of the United States of America1997
smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 91 citations in OpenAlex.
- Review
- Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the mouse craniofacial development.iScience · 2025Article
- Physiological Consequences of Nonsense-Mediated Decay and Its Role in Adaptive Responses.Biomedicines · 2024Review
- The rice blast fungus SR protein 1 regulates alternative splicing with unique mechanisms.PLoS pathogens · 2022Article
- Translational repression of NMD targets by GIGYF2 and EIF4E2.PLoS genetics · 2021Article
- Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways.Genome biology · 2021Article
- mRNA Editing, Processing and Quality Control inGenetics · 2020Review
- The Substrates of Nonsense-Mediated mRNA Decay inG3 (Bethesda, Md.) · 2018Article
- Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity.Nature communications · 2017Article
- Evolutionarily conserved autoregulation of alternative pre-mRNA splicing by ribosomal protein L10a.Nucleic acids research · 2016Article
- Physiological and pathophysiological role of nonsense-mediated mRNA decay.Pflugers Archiv : European journal of physiology · 2016Review
- Complexity of the alternative splicing landscape in plants.The Plant cell · 2013Review
- Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.BMC genomics · 2013Article
- Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox.International journal of cell biology · 2013Review
- A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegans.Molecular and cellular biology · 2013Article
- Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans.Genome research · 2012Article
- Characterization and genetic analysis of an EIN4-like sequence (CaETR-1) located in QTL(AR1) implicated in ascochyta blight resistance in chickpea.Plant cell reports · 2012Article
- Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns.Genome biology · 2012Article
- Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana.Biology direct · 2010Article
- Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.BMC genomics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The expression of alternatively spliced mRNAs from genes is an ubiquitous phenomenon in metazoa. A screen for trans-acting factors that alter the expression of alternatively spliced mRNAs reveals that the smg genes of Caenorhabditis elegans participate in this process. smg genes have been proposed to function in degradation of nonsense mutant mRNAs. Here we show that smg genes affect normal gene expression by modulating the levels of alternatively spliced SRp20 and SRp30b mRNAs. These SR genes contain alternatively spliced exons that introduce upstream stop codons. The effect of smg genes on SR transcripts is specific, because the gene encoding the catalytic subunit of the cAMP-dependent protein kinase, which also contains an alternatively spliced exon that introduces upstream stop codon, is not effected in a smg background. These results suggest that the levels of alternatively spliced mRNAs may, in part, be regulated by alternative mRNA stability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.