ArticleProceedings of the National Academy of Sciences of the United States of America1997
Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Article
- Evolution of cis-regulatory modules for the head organizer geneZoological letters · 2019Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus.Developmental biology · 2014Article
- Lim1/LIM1 is expressed in developing and adult mouse and human endometrium.Histochemistry and cell biology · 2012Article
- Characterization of Cer-1 cis-regulatory region during early Xenopus development.Development genes and evolution · 2011Article
- The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps.BMC developmental biology · 2011Article
- Characterization of an lhx1a transgenic reporter in zebrafish.The International journal of developmental biology · 2010Article
- Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field.Development (Cambridge, England) · 2009Article
- An amphioxus LIM-homeobox gene, AmphiLim1/5, expressed early in the invaginating organizer region and later in differentiating cells of the kidney and central nervous system.International journal of biological sciences · 2006Article
- Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos.The EMBO journal · 1998Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The Xlim-1 gene is activated in the late blastula stage of Xenopus embryogenesis in the mesoderm, and its RNA product becomes concentrated in the Spemann organizer at early gastrula stage. A major regulator of early expression of Xlim-1 is activin or an activin-like signal. We report experiments aiming to identify the activin response element in the Xlim-1 gene. The 5' flanking region of the gene contains a constitutive promoter that is not activin responsive, whereas sequences in the first intron mediate repression of basal promoter activity and stimulation by activin. An intron-derived fragment of 212 nt is the smallest element that could mediate activin responsiveness. Nodal and act-Vg1, factors with signaling properties similar to activin, also stimulated Xlim-1 reporter constructs, whereas BMP-4 did not stimulate or repress the constructs. The mechanism of activin regulation of Xlim-1 and the sequence of the response element are distinct from activin response elements of other genes studied so far.
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