ArticleBritish journal of cancer1997
Stromal tenascin distribution as a prognostic marker in colorectal cancer.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Tenascin-C expression in the lymph node pre-metastatic niche in muscle-invasive bladder cancer.British journal of cancer · 2021Article
- The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.PloS one · 2015Article
- Article
- A migration signature and plasma biomarker panel for pancreatic adenocarcinoma.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Clinical significance of large tenascin-C spliced variant as a potential biomarker for colorectal cancer.World journal of surgery · 2007Article
- Tenascin C expression is upregulated in pancreatic cancer and correlates with differentiation.Journal of clinical pathology · 2004Article
- Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer.Journal of clinical pathology · 2004Article
- Tenascin immunoreactivity in the large bowel and the liver in patients with colorectal cancer.The Histochemical journal · 2001Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 169 colorectal adenocarcinomas, obtained from patients with a median follow-up of 6.5 years, were studied with immunohistochemical staining on cryosections using a monoclonal anti-tenascin antibody to evaluate the possible association between the staining patterns and tumour stage, tumour differentiation and survival. We found two different staining patterns in the tumour stroma--a diffuse stromal fibrillar staining in 92 out of 169 (54%) tumours and a subglandular staining in the remaining 77 tumours. When the entire group of patients (P < 0.01) and the group of potentially cured patients (P < 0.03) were analysed univariately, it was found that diffuse stromal fibrillar staining was associated with a shorter survival time than subglandular staining. In a multivariate analysis, the Dukes' stage and age were independent prognostic factors, whereas the tenascin expression did not retain a clear independent relationship to survival (P = 0.06). Hence, it appears that the tumour expression of tenascin may be a potential prognostic marker in colorectal cancer, in so far as a diffuse stromal fibrillar staining pattern seems to indicate an increased risk of poor outcome. However, after adjustment for age and Dukes' stage, the additional prognostic value of tenascin remains to be established in further analyses.
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