ArticleGut1997
DNA viruses in the pathogenesis of sporadic chronic idiopathic intestinal pseudo-obstruction.
Article in Gut, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Guideline
- Clinical guideline: management of gastroparesis.The American journal of gastroenterology · 2013Guideline
- Ten controversies in gastroparesis and a look to the future.Neurogastroenterology and motility · 2023Review
- Patients with Specific Gastrointestinal Motility Disorders are Commonly Diagnosed as Functional GI Disorders in the Early Stage by Community Physicians due to Lack of Awareness.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Could Chronic Idiopatic Intestinal Pseudo-Obstruction Be Related to Viral Infections?Journal of clinical medicine · 2021Review
- You Talking to Me? Says the Enteric Nervous System (ENS) to the Microbe. How Intestinal Microbes Interact with the ENS.Journal of clinical medicine · 2020Review
- Article
- HSV1/2 Genital Infection in Mice Cause Reversible Delayed Gastrointestinal Transit: A Model for Enteric Myopathy.Frontiers in medicine · 2018Article
- Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis.Digestive diseases and sciences · 2016Article
- Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality.Cell host & microbe · 2016Article
- Infected peripheral blood mononuclear cells transmit latent varicella zoster virus infection to the guinea pig enteric nervous system.Journal of neurovirology · 2014Article
- JC Virus, Helicobacter pylori, and oesophageal achalasia: preliminary results from a retrospective case-control study.Digestive diseases and sciences · 2013Article
- What are the important subsets of gastroparesis?Neurogastroenterology and motility · 2012Review
- Ileocecal intussusception with histomorphological features of inflammatory neuropathy in adenovirus infection.Gastroenterology research and practice · 2009Article
- JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction.Gut · 2009Article
- Chronic intestinal pseudo-obstruction.World journal of gastroenterology · 2008Review
- Fatal acute intestinal pseudoobstruction in mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2008Article
- Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts.The American journal of pathology · 2006Article
- Chronic Intestinal Pseudo-Obstruction.Current treatment options in gastroenterology · 2005Article
- Small bowel review: normal physiology part 2.Digestive diseases and sciences · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHereditary forms of chronic idiopathic intestinal pseudo-obstruction (CIIP) are well described but the aetiology of most cases of sporadic CIIP is unknown.
aimTo determines whether herpes viruses can persist in the gastrointestinal tract, thereby implicating them in the pathogenesis of CIIP.
methodsTwenty one specimens of small and large intestine from 13 patients with CIIP (eight visceral myopathy, three visceral neuropathy, two undifferentiated), and 12 patients operated on for colorectal cancer (controls) were examined for evidence of Herpesvirus DNA (cytomegalovirus, Epstein-Barr virus (EBV), herpes simplex virus type 1, and varicella zoster virus) by nested polymerase chain reaction (PCR) and in situ DNA hybridisation (ISH) to localise signal to the muscularis propria or myenteric plexus.
resultsScreening with nested PCR produced three patients with positive results. One patient with an inflammatory visceral neuropathy had EBV detected in the small intestine by PCR, and ISH demonstrated localisation to neurones in the myenteric plexus. A patient with a visceral myopathy had EBV DNA in both the small and large intestine; and one patient with a visceral neuropathy had small intestine positive for CMV DNA (both negative by ISH). No control tissue was positive for any virus.
conclusionsIn individual patients there appears to be evidence linking a viral aetiology to sporadic CIIP. The role of neurotropic viruses in acute and chronic motility disturbances needs further study.
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