ArticleThe American journal of pathology1997
Extrasynaptic location of laminin beta 2 chain in developing and adult human skeletal muscle.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins.Fluids and barriers of the CNS · 2022Article
- The Multiple Faces of Integrin-ECM Interactions in Inflammatory Bowel Disease.International journal of molecular sciences · 2021Review
- Deciphering the regulation of porcine genes influencing growth, fatness and yield-related traits through genetical genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Laminin-database v.2.0: an update on laminins in health and neuromuscular disorders.Nucleic acids research · 2014Article
- Laminin production and basement membrane deposition by mesenchymal stem cells upon adipogenic differentiation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- ISPD gene mutations are a common cause of congenital and limb-girdle muscular dystrophies.Brain : a journal of neurology · 2013Article
- Disruption of basal lamina components in neuromotor synapses of children with spastic quadriplegic cerebral palsy.PloS one · 2013Article
- Tissue distribution of the laminin beta1 and beta2 chain during embryonic and fetal human development.Journal of molecular histology · 2010Article
- Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support.Journal of cellular and molecular medicine · 2009Article
- Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.Histochemistry and cell biology · 2008Article
- Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: implications for Pierson syndrome.Development (Cambridge, England) · 2006Article
- Characterisation of human soft palate muscles with respect to fibre types, myosins and capillary supply.Journal of anatomy · 2000Article
- Expression of laminins and their integrin receptors in different conditions of synovial membrane and synovial membrane-like interface tissue.Annals of the rheumatic diseases · 1999Article
- A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.Molecular and cellular biology · 1999Article
- Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy.The Journal of clinical investigation · 1997Article
- Elevated cell invasion is induced by hypoxia in a human pituitary adenoma cell line.Cell adhesion & migrationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the distribution of the laminin beta 2 chain (previously s-laminin) in human fetal and adult skeletal muscle and compared it to the distribution of laminin beta 1. Immunoblotting and transfection assays were used to characterize a panel of monoclonal and polyclonal antibodies to the laminin beta 2 chain. We found that laminin beta 1 chain was detected at all times during development from 10 weeks of gestation. Laminin beta 2 chain was first detected in 15 to 22-week-old fetal skeletal muscle as distinct focal immunoreactivity in the sarcolemmal basement membrane area of some myofibers. In the adult skeletal muscle, laminin beta 2 chain immunoreactivity was found along the entire perimeter of each of the individual myofibers in a large series of different muscles studied. Laminin beta 2 chain was similarly found in the skeletal muscle basement membranes in patients with Duchenne and Becker muscular dystrophy. Immunoaffinity chromatography of muscle extracts with a monoclonal antibody to the laminin alpha 2 chain followed by immunoblotting with various antibodies to the beta 2 chain demonstrated the presence of the laminin-4 (alpha 2-beta 2-gamma 1) isoform. Together the present results demonstrate a prominent extrasynaptic localization of laminin beta 2 in the human muscle, suggesting that it may have an important function in the sarcolemmal basement membrane.
Indexed as
Identifiers
9273822PMC1858019W141657229What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.