ArticleThe Journal of experimental medicine1997
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 185 citations in OpenAlex.
- Trial
- New Insights into the Role of the Complement System in Human Viral Diseases.Biomolecules · 2022Review
- Absence of complement factor H reduces physical performance in C57BL6 mice.Immunobiology · 2020Article
- Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.Science immunology · 2017Article
- The relative merits of therapies being developed to tackle inappropriate ('self'-directed) complement activation.Auto- immunity highlights · 2016Article
- RP S19 C-terminal peptide trimer acts as a C5a receptor antagonist.Biochemistry and biophysics reports · 2016Article
- Association between IgG4 Autoantibody and Complement Abnormalities in Systemic Lupus Erythematosus.Mediators of inflammation · 2016Article
- Immune Complex-Induced, Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes Is Prevented with Decoy FcγReceptors.PloS one · 2016Article
- Cutting edge: critical role for C5aRs in the development of septic lymphopenia in mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- A virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A provides protection against viral challenge without priming for enhanced disease in cotton rats.Influenza and other respiratory viruses · 2013Article
- iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.The Journal of clinical investigation · 2013Article
- The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice.Kidney international · 2012Article
- Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.PloS one · 2012Article
- The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.The Journal of biological chemistry · 2010Article
- Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction.The American journal of pathology · 2010Article
- Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies.Blood · 2009Article
- Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction.The American journal of pathology · 2009Article
- Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs.Shock (Augusta, Ga.) · 2009Article
- Functions of C5a receptors.Journal of molecular medicine (Berlin, Germany) · 2009Review
- Peanuts can contribute to anaphylactic shock by activating complement.The Journal of allergy and clinical immunology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We recently demonstrated that gene-targeted disruption of the C5a anaphylatoxin receptor prevented lung injury in immune complex-mediated inflammation. In this study, we compare the effect of C5aR deficiency in immune complex-induced inflammation in the peritoneal cavity and skin with the results derived from our immune complex alveolitis model. C5aR- deficient mice exhibit decreased migration of neutrophils and decreased levels of TNF-alpha and interleukin 6 in the peritoneal reverse passive Arthus reaction compared to their wild-type littermates. In the reverse passive Arthus reaction in the skin the C5aR was also required for the full expression of neutrophil influx and edema formation; C5aR-deficient mice showed reduced neutrophil migration and microvascular permeability changes. In contrast to our studies in immune complex-induced lung inflammation, C5aR deficiency does not completely prevent injury in the peritoneal cavity and skin. These data indicate a dominant role for the C5aR and its ligand in the reverse passive Arthus reaction in the lung and a synergistic role together with other inflammatory mediators in immune complex-mediated peritonitis and skin injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.