ArticleThe Journal of experimental medicine1997
High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 286 citations in OpenAlex.
- A Therapeutic Vaccine in Combination with Cyclic GMP-AMP Cures More Differentiated Melanomas in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Identification of dendritic cell precursor from the CD11cFrontiers in immunology · 2023Article
- Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function.Cell reports · 2022Article
- Neuroinflammation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia and the Interest of Induced Pluripotent Stem Cells to Study Immune Cells Interactions With Neurons.Frontiers in molecular neuroscience · 2021Review
- Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting.Cancers · 2020Review
- Effects of disodium cantharidinate on dendritic cells of patients with bladder carcinoma.Oncology letters · 2018Article
- A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice.Cellular immunology · 2015Article
- Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma.Journal of experimental & clinical cancer research : CR · 2015Article
- Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major.Antimicrobial agents and chemotherapy · 2014Article
- Macrophage polarization and activation in response to implant debris: influence by "particle disease" and "ion disease".Journal of long-term effects of medical implants · 2014Article
- Antigen-specific immune reactions to ischemic stroke.Frontiers in cellular neuroscience · 2014Review
- Monocyte Expressed Macromolecular C1 and C1q Receptors as Molecular Sensors of Danger: Implications in SLE.Frontiers in immunology · 2014Review
- Immunotherapy for colorectal cancer.World journal of gastroenterology · 2013Review
- Impact of PRRSV on activation and viability of antigen presenting cells.World journal of virology · 2013Review
- Macrophages-Key cells in the response to wear debris from joint replacements.Journal of biomedical materials research. Part A · 2013Review
- Targeting the B7 family of co-stimulatory molecules: successes and challenges.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2013Review
- Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines.Journal of biomedicine & biotechnology · 2011Review
- Article
- Adjuvant engineering for cancer immunotherapy: Development of a synthetic TLR2 ligand with increased cell adhesion.Cancer science · 2010Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
T lymphocytes recirculate continually through the T cell areas of peripheral lymph nodes. During each passage, the T cells survey the surface of large dendritic cells (DCs), also known as interdigitating cells. However, these DCs have been difficult to release from the lymph node. By emphasizing the use of calcium-free media, as shown by Vremec et al. (Vremec, D., M. Zorbas, R. Scollay, D.J. Saunders, C.F. Ardavin, L. Wu, and K. Shortman. 1992. J. Exp. Med. 176:47-58.), we have been able to release and enrich DCs from the T cell areas. The DCs express the CD11c leukocyte integrin, the DEC-205 multilectin receptor for antigen presentation, the intracellular granule antigens which are recognized by monoclonal antibodies M342, 2A1, and MIDC-8, very high levels of MHC I and MHC II, and abundant accessory molecules such as CD40, CD54, and CD86. When examined with the Y-Ae monoclonal which recognizes complexes formed between I-Ab and a peptide derived from I-Ealpha, the T cell area DCs expressed the highest levels. The enriched DCs also stimulated a T-T hybridoma specific for this MHC II-peptide complex, and the hybridoma underwent apoptosis. Therefore DCs within the T cell areas can be isolated. Because they present very high levels of self peptides, these DCs should be considered in the regulation of self reactivity in the periphery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.