ArticleMolecular and cellular biology1997
The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Proximity labeling reveals interactions necessary to maintain the distinct apical domains of Drosophila photoreceptors.Journal of cell science · 2024Article
- Compound dominant-null heterozygosity in a family withAmerican journal of ophthalmology case reports · 2022Article
- Dominant RP in the Middle While Recessive in Both the N- and C-Terminals Due toFrontiers in cell and developmental biology · 2021Article
- BiallelicMolecular vision · 2020Article
- Molecular Chaperone Hsp70 and Its Constitutively Active Form Hsc70 Play an Indispensable Role During Eye Development of Drosophila melanogaster.Molecular neurobiology · 2018Article
- Flubendiamide affects visual and locomotory activities of Drosophila melanogaster for three successive generations (P, FInvertebrate neuroscience : IN · 2018Article
- Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes.Molecular and cellular biology · 2011Article
- Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.Molecular and cellular neurosciences · 2008Article
- Protein kinase D regulates several aspects of development in Drosophila melanogaster.BMC developmental biology · 2007Article
- Dissecting Nck/Dock signaling pathways in Drosophila visual system.International journal of biological sciences · 2005Review
- WASp is required for the correct temporal morphogenesis of rhabdomere microvilli.The Journal of cell biology · 2004Article
- Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes.Genes & development · 2004Article
- Expression of Drosophila Ca2+ permeable transient receptor potential-like channel protein in a prostate cancer cell line decreases cell survival.Cancer gene therapy · 2003Article
- A novel mutation of the RP1 gene (Lys778ter) associated with autosomal dominant retinitis pigmentosa.The British journal of ophthalmology · 2002Article
- Twinfilin is required for actin-dependent developmental processes in Drosophila.The Journal of cell biology · 2001Article
- RotundRacGAP functions with Ras during spermatogenesis and retinal differentiation in Drosophila melanogaster.Molecular and cellular biology · 2001Article
- Article
- Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye.Molecular and cellular biology · 2001Article
- Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization.The Journal of cell biology · 2000Article
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3 authors.
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Abstract
Photoreceptor cells of the Drosophila compound eye begin to develop specialized membrane foldings at the apical surface in midpupation. The microvillar structure ultimately forms the rhabdomere, an actin-rich light-gathering organelle with a characteristic shape and morphology. In a P-element transposition screen, we isolated mutations in a gene, bifocal (bif), which is required for the development of normal rhabdomeres. The morphological defects seen in bif mutant animals, in which the distinct contact domains established by the newly formed rhabdomeres are abnormal, first become apparent during midpupal development. The later defects seen in the mutant adult R cells are more dramatic, with the rhabdomeres enlarged, elongated, and frequently split. bif encodes a novel putative protein of 1063 amino acids which is expressed in the embryo and the larval eye imaginal disc in a pattern identical to that of F actin. During pupal development, Bif localizes to the base of the filamentous actin associated with the forming rhabdomeres along one side of the differentiating R cells. On the basis of its subcellular localization and loss-of-function phenotype, we discuss possible roles of Bif in photoreceptor morphogenesis.
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