ArticleMolecular and cellular biology1997
Transient expression of a winged-helix protein, MNF-beta, during myogenesis.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.Nature communications · 2019Article
- FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.Nature communications · 2019Article
- FOXK1 interaction with FHL2 promotes proliferation, invasion and metastasis in colorectal cancer.Oncogenesis · 2016Article
- Direct regulation of FOXK1 by C-jun promotes proliferation, invasion and metastasis in gastric cancer cells.Cell death & disease · 2016Article
- Regulation of myoglobin expression.The Journal of experimental biology · 2010Review
- Hypoxia reprograms calcium signaling and regulates myoglobin expression.American journal of physiology. Cell physiology · 2009Article
- FoxK mediates TGF-beta signalling during midgut differentiation in flies.The Journal of cell biology · 2008Article
- Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF.Nucleic acids research · 2007Article
- Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin.The Journal of physiology · 2003Article
- 1H, 15N and 13C resonance assignments for the DNA-binding domain of myocyte nuclear factor (Foxk1).Journal of biomolecular NMR · 2002Article
- Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration.The Journal of cell biology · 2002Article
- Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation.Genes & development · 2001Article
- Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing.The Journal of cell biology · 2000Article
- Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.The EMBO journal · 2000Article
- Article
- PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.Molecular and cellular biology · 2000Article
- The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B.The Biochemical journal · 2000Article
- Temporal activation of the sea urchin late H1 gene requires stage-specific phosphorylation of the embryonic transcription factor SSAP.Molecular and cellular biology · 1999Article
- Insulin-like growth factor (IGF-I) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in a clonal skeletal-muscle cell model.The Biochemical journal · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A novel winged-helix transcription factor, MNF-beta, is expressed coincidentally with cell cycle withdrawal and differentiation of skeletal myogenic cells. MNF-beta is closely related to the myocyte nuclear factor (MNF) protein previously described (now termed MNF-alpha), but expression of the two isoforms is differentially regulated, and they exhibit distinctive functional properties with respect to DNA binding in vitro and transcriptional regulatory activity in transient-transfection assays. A DNA sequence motif binding MNF-beta with high affinity was selected from a library of random oligonucleotides and was found to be similar to but distinct from the cognate binding site for HNF-3beta, a more distantly related winged-helix protein. The temporal pattern of MNF-beta expression and the presence of MNF binding motifs within conserved promoter elements of several genes that modulate cell cycle progression support a working hypothesis that MNF proteins may modulate proliferation of myogenic precursor cells during development and muscle regeneration.
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