ArticleMolecular and cellular biology1997
Hepatocyte nuclear factor 1alpha gene inactivation impairs chromatin remodeling and demethylation of the phenylalanine hydroxylase gene.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns.Journal of diabetes · 2023Review
- Transcriptional control by HNF-1: Emerging evidence showing its role in lipid metabolism and lipid metabolism disorders.Genes & diseases · 2022Review
- Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer.PloS one · 2015Article
- Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.The Journal of biological chemistry · 2010Article
- A mitotic transcriptional switch in polycystic kidney disease.Nature medicine · 2010Article
- Review
- Association of differential and site-dependent CpG methylation and diverse expression of DNA methyltransferases with the tissue-specific expression of human beta-globin gene in transgenic mice.International journal of hematology · 2009Article
- A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.Journal of cellular and molecular medicine · 2009Article
- Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets.PLoS genetics · 2008Article
- Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells.Nucleic acids research · 2008Article
- Distinct pathways of genomic progression to benign and malignant tumors of the liver.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300.Molecular and cellular biology · 2004Article
- HNF1alpha is involved in tissue-specific regulation of CFTR gene expression.The Biochemical journal · 2004Article
- Effects of dietary glycerol on the expression of pterin carbinolamine dehydratase in the rat.The Biochemical journal · 2003Article
- Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3.Diabetologia · 2003Article
- Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes.The Journal of experimental medicine · 2001Article
- Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes.Molecular and cellular biology · 2001Article
- Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets.Molecular and cellular biology · 2001Article
- HNF1alpha controls renal glucose reabsorption in mouse and man.EMBO reports · 2000Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocyte nuclear factor 1 alpha (HNF1alpha) is a homeoprotein that is expressed in the liver, kidney, pancreas, and digestive tract. Its inactivation in mouse resulted in decreased transcription of known target genes such as albumin and alpha1-antitrypsin. In contrast, the phenylalanine hydroxylase (PAH) gene was totally silent and unresponsive to normal inducers like glucocorticoids and cyclic AMP in the liver. DNase I and micrococcal nuclease digestion of liver nuclei showed that HNF1alpha inactivation had drastic effects on the chromatin structure of the PAH regulatory regions. Three DNase I-hypersensitive sites (HSSI, HSSII, and HSSIII), typical of the actively transcribed PAH gene, were undetectable in liver from HNF1alpha-deficient animals. Both HSSII and HSSIII elements harbor HNF1 sites, but only the latter has detectable enhancer activity in transient-transfection assays. In addition, the PAH promoter in livers of HNF1alpha-deficient animals was methylated. These results suggest that HNF1alpha could activate transcription through two mechanisms. One implies participation in the recruitment of the general transcription machinery to the promoter, and the second involves the remodeling of chromatin structure and demethylation that would allow transcription factors to interact with their cognate cis-acting elements.
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