ArticleThe Journal of physiology1997
Hyperpolarization of isolated capillaries from guinea-pig heart induced by K+ channel openers and glucose deprivation.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Detection of Membrane Potential-Dependent Rhodopsin Fluorescence Using Low-Intensity Light Emitting Diode for Long-Term Imaging.ACS omega · 2023Article
- The interplay of intracellular calcium and zinc ions in response to electric field stimulation in primary rat cortical neuronsFrontiers in cellular neuroscience · 2023Article
- Adenosine signaling activates ATP-sensitive KScience signaling · 2022Article
- Age-related impairment of cerebral blood flow response to KJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac KThe Journal of physiology · 2018Article
- Cardiovascular KPathobiology of aging & age related diseases · 2016Review
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.Immunity · 2013Article
- Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system.Circulation. Arrhythmia and electrophysiology · 2011Article
- The anti-botulism triterpenoid toosendanin elicits calcium increase and exocytosis in rat sensory neurons.Cellular and molecular neurobiology · 2011Article
- Transcriptional remodeling of ion channel subunits by flow adaptation in human coronary artery endothelial cells.Journal of vascular research · 2011Article
- Regulation of smooth muscle contractility by the epithelium in rat vas deferens: role of ATP-induced release of PGE2.The Journal of physiology · 2008Article
- Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.The Journal of physiology · 2006Article
- Stimulation of sodium pump restores membrane potential to neurons excited by glutamate in zebrafish distal retina.The Journal of physiology · 2003Article
- ATP-sensitive potassium channels in capillaries isolated from guinea-pig heart.The Journal of physiology · 2000Article
- Levcromakalim causes indirect endothelial hyperpolarization via a myo-endothelial pathway.British journal of pharmacology · 1999Article
- Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A.British journal of pharmacology · 1999Article
- Pharmacological evidence for a KATP channel in renin-secreting cells from rat kidney.The Journal of physiology · 1999Article
- Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia.The Journal of physiology · 1999Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The present study was designed to test if microvascular coronary endothelial cells express ATP-sensitive K+ channels (KATP channels). We performed microfluorometric measurements of the membrane potential of freshly isolated guinea-pig coronary capillaries equilibrated with the voltage-sensitive dye bis-oxonol (bis-[1,3-dibutylbarbituric acid] trimethineoxonol, [DiBAC4(3)]). 2. The resting membrane potential of capillaries in physiological salt solution was -46 +/- 4.2 mV (n = 8) at room temperature (22 degrees C) as determined after calibration of the fluorescence using the Na(+)-K+ ionophore gramicidin in the presence of different K+ concentrations. Spontaneous membrane potential fluctuations of 10-20 mV amplitude were often observed. 3. A reversible, sustained hyperpolarization to a new membrane potential close to the K+ equilibrium potential (EK) could be induced by application of the K+ channel openers HOE 234 (100 nM to 1 microM), diazoxide (10 PM to 100 nM) or pinacidil (100 nM). Subsequent addition of glibenclamide (200 nM to 2 microM) reversed this hyperpolarization. 4. A glibenclamide-sensitive hyperpolarization of coronary capillaries to values near EK was also observed upon omission of D-glucose (10 mM) from the superfusing solution or by substituting L-glucose for D-glucose. Maximum hyperpolarization was reached in less than 10 min. 5. Our results suggest that microvascular coronary endothelial cells express KATP channels which may be activated during hypoglycaemia.
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