ArticleThe Journal of physiology1997
Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 135 citations in OpenAlex.
- A multimodal electrochemical approach to measure the effect of zinc on vesicular content and exocytosis in a single cell model of ischemia.QRB discovery · 2021Article
- Role of IP3 Receptors in Shaping the Carotid Chemoreceptor Response to Hypoxia But Not to Hypercapnia in the Rat Carotid Body: An Evidence Review.Advances in experimental medicine and biology · 2021Article
- Modeling the effects of extracellular potassium on bursting properties in pre-Bötzinger complex neurons.Journal of computational neuroscience · 2016Article
- Conformational dynamics of shaker-type Kv1.1 ion channel in open, closed, and two mutated states.The Journal of membrane biology · 2015Article
- Oxidative modulation of voltage-gated potassium channels.Antioxidants & redox signaling · 2014Review
- Moderate hypoxia influences potassium outward currents in adipose-derived stem cells.PloS one · 2014Article
- TRP channels as sensors of oxygen availability.Pflugers Archiv : European journal of physiology · 2013Review
- Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Modulation of voltage-gated K+ channels by the sodium channel β1 subunit.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Hypoxia induces voltage-gated K+ (Kv) channel expression in pulmonary arterial smooth muscle cells through hypoxia-inducible factor-1 (HIF-1).Bosnian journal of basic medical sciences · 2012Article
- Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.American journal of physiology. Cell physiology · 2012Article
- Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes.The Journal of biological chemistry · 2012Article
- Permeation and block of the Kv1.2 channel examined using brownian and molecular dynamics.Biophysical journal · 2011Article
- Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells.Biophysical journal · 2009Article
- Regulation of the Kv2.1 potassium channel by MinK and MiRP1.The Journal of membrane biology · 2009Article
- A case of serendipity*.Purinergic signalling · 2008Article
- Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels.The Journal of physiology · 2006Article
- Moderate hypoxia influences excitability and blocks dendrotoxin sensitive K+ currents in rat primary sensory neurones.Molecular pain · 2006Article
- Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein.The Journal of physiology · 2006Article
- Down regulation of Kv3.4 channels by chronic hypoxia increases acute oxygen sensitivity in rabbit carotid body.The Journal of physiology · 2005Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
1. Electrophysiological (single-channel patch clamp) and molecular biological experiments (reverse transcriptase-polymerase chain reaction) were performed to attempt to identify the O2-sensitive K+ channel in rat phaeochromocytoma (PC12) cells. 2. Four types of K+ channels were recorded in PC12 cells: a small-conductance K+ channel (14 pS), a calcium-activated K+ channel (KCa; 102 pS) and two K+ channels with similar conductance (20 pS). These last two channels differed in their time-dependent inactivation: one was a slow-inactivating channel, while the other belonged to the family of fast transient K+ channels. 3. The slow-inactivating 20 pS K+ channel was inhibited by hypoxia. Exposure to hypoxia produced a 50% reduction in channel activity (number of active channels in the patch x open probability). Hypoxia had no effect on the 20 pS transient K+ channels, whereas reduced O2 stimulated the KCa channels. 4. The genes encoding the alpha-subunits of slow-inactivating K+ channels for two members of the Shaker subfamily of K+ channels (Kv1.2 and Kv1.3) together with the Kv2.1, Kv3.1 and Kv3.2 channel genes were identified in PC12 cells. 5. The expression of the Shaker Kv1.2, but none of the other K+ channel genes, increased in cells exposed to prolonged hypoxia (18 h). The same cells were more responsive to a subsequent exposure to hypoxia (35% inhibition of K+ current measured in whole-cell voltage clamp) compared with the cells maintained in normoxia (19% inhibition). 6. These results indicate that the O2-sensitive K+ channel in PC12 cells is a 20 pS slow-inactivating K+ channel that is upregulated by hypoxia. This channel appears to belong to the Shaker subfamily of voltage-gated K+ channels.
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