ArticleJournal of virology1997
A single amino acid substitution in the transmembrane envelope glycoprotein of feline immunodeficiency virus alters cellular tropism.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Evolutionary ecology of virus emergence.Annals of the New York Academy of Sciences · 2017Review
- Article
- Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012Review
- Strain-specific viral distribution and neuropathology of feline immunodeficiency virus.Veterinary immunology and immunopathology · 2011Article
- Genomic organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wild.BMC genomics · 2008Article
- Probing the interaction between feline immunodeficiency virus and CD134 by using the novel monoclonal antibody 7D6 and the CD134 (Ox40) ligand.Journal of virology · 2007Article
- Characterization of a highly pathogenic molecular clone of feline immunodeficiency virus clade C.Journal of virology · 2004Article
- Ramified feline microglia selects for distinct variants of feline immunodeficiency virus during early central nervous system infection.Journal of neurovirology · 2003Article
- Evolution of cell recognition by viruses: a source of biological novelty with medical implications.Advances in virus research · 2003Review
- Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence.Journal of virology · 2002Article
- Feline immunodeficiency virus xenoinfection: the role of chemokine receptors and envelope diversity.Journal of virology · 2002Article
- Envelope gene-mediated neurovirulence in feline immunodeficiency virus infection: induction of matrix metalloproteinases and neuronal injury.Journal of virology · 2002Article
- Article
- Expanded host cell tropism and cytopathic properties of feline immunodeficiency virus strain PPR subsequent to passage through interleukin-2-independent T cells.Journal of virology · 2000Article
- Second-site changes affect viability of amphotropic/ecotropic chimeric enveloped murine leukemia viruses.Journal of virology · 2000Article
- Shared usage of the chemokine receptor CXCR4 by primary and laboratory-adapted strains of feline immunodeficiency virus.Journal of virology · 1999Article
- Differential cell tropism of feline immunodeficiency virus molecular clones in vivo.Journal of virology · 1999Article
- Productive infection of human peripheral blood mononuclear cells by feline immunodeficiency virus: implications for vector development.Journal of virology · 1999Article
- The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular tropism of the feline immunodeficiency virus (FIV) is affected by changes in variable region 3 (V3) of the surface (SU) envelope glycoprotein (Verschoor, E. J., et al., J. Virol. 69:4752-4757, 1995). By using high-dose DNA transfection, an FIV molecular clone with a non-CRFK-tropic V3 acquired the ability to replicate in CRFK cells. A single point mutation from a methionine to a threonine in the ectodomain of its transmembrane (TM) envelope glycoprotein was responsible for this change in viral tropism. This substitution is located in the putative SU interactive region, between the fusion peptide and the membrane-spanning region. Our results show that this region of the TM envelope glycoprotein constitutes an additional determinant for cell tropism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.