ArticleJournal of virology1997
The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- OncogeneScience advances · 2024Article
- CBAdvances in pharmacology (San Diego, Calif.) · 2017Review
- Cannabinoid receptors: nomenclature and pharmacological principles.Progress in neuro-psychopharmacology & biological psychiatry · 2012Review
- CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity.Journal of psychopharmacology (Oxford, England) · 2012Review
- Pharmacological characterization of GPR55, a putative cannabinoid receptor.Pharmacology & therapeutics · 2010Review
- Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Cannabinoids and cancer: pros and cons of an antitumour strategy.British journal of pharmacology · 2006Review
- Animal models of acute myelogenous leukaemia - development, application and future perspectives.Leukemia · 2005Review
- The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia.Journal of virology · 2005Article
- Article
- Genetic heterogeneity in acute myeloid leukemia: maximizing information flow from MuLV mutagenesis studies.Leukemia · 2000Review
- Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new common region of virus integration, Evi11, has been identified in two retrovirally induced murine myeloid leukemia cell lines, NFS107 and NFS78. By interspecific backcross analysis, it was shown that Evi11 is located at the distal end of mouse chromosome 4, in a region that shows homology with human 1p36. The genes encoding the peripheral cannabinoid receptor (Cnr2) and alpha-L-fucosidase (Fuca1) were identified near the integration site by using a novel exon trapping system. Cnr2 is suggested to be the target gene for viral interference in Evi11, since proviruses are integrated in the first intron of Cnr2 and retroviral integrations alter mRNA expression of Cnr2 in NFS107 and NFS78. In addition, proviral integrations were demonstrated within the 3' untranslated region of Cnr2 in five independent newly derived CasBrM-MuLV (mouse murine leukemia virus) tumors, CSL13, CSL14, CSL16, CSL27, and CSL97. The Cnr2 gene encodes a seven-transmembrane G-protein-coupled receptor which is normally expressed in hematopoietic tissues. Our data suggest that the peripheral cannabinoid receptor gene might be involved in leukemogenesis as a result of aberrant expression of Cnr2 due to retroviral integration in Evi11.
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