ArticleJournal of virology1997
Glycoprotein Erns of pestiviruses induces apoptosis in lymphocytes of several species.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 112 citations in OpenAlex.
- Structural and electrostatic determinants of RNA recognition by the CSFV Erns glycoprotein.Archives of virology · 2026Article
- Review
- First Identification, Recombinant Production, and Structural Characterization of a Putative Structural Protein from the Haseki Tick Virus Polyprotein.Biomolecules · 2025Article
- Classical Swine Fever Virus Envelope Glycoproteins EBiomolecules · 2025Article
- Host cell factors involved in classical swine fever virus entry.Veterinary research · 2023Review
- Strengths and Challenges of Secretory Ribonucleases as AntiTumor Agents.Pharmaceutics · 2021Review
- Article
- Apoptosis, Autophagy, and Pyroptosis: Immune Escape Strategies for Persistent Infection and Pathogenesis of Classical Swine Fever Virus.Pathogens (Basel, Switzerland) · 2019Review
- Complex Virus-Host Interactions Involved in the Regulation of Classical Swine Fever Virus Replication: A Minireview.Viruses · 2017Review
- Review
- Article
- Apoptosis induced in vivo by new type gosling viral enteritis virus.Journal of veterinary science · 2011Article
- T2 Family ribonucleases: ancient enzymes with diverse roles.Trends in biochemical sciences · 2010Review
- Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling.World journal of gastroenterology · 2008Article
- Purified bovine plasma blocking factor decreases Bovine leukemia virus p24 expression while increasing protein synthesis and transcriptional activity of peripheral blood mononuclear cells in short-term culture.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2005Article
- Determinants of virulence of classical swine fever virus strain Brescia.Journal of virology · 2004Article
- Avian reoviruses cause apoptosis in cultured cells: viral uncoating, but not viral gene expression, is required for apoptosis induction.Journal of virology · 2002Article
- Interaction of classical swine fever virus with membrane-associated heparan sulfate: role for virus replication in vivo and virulence.Journal of virology · 2001Article
- Passage of classical swine fever virus in cultured swine kidney cells selects virus variants that bind to heparan sulfate due to a single amino acid change in envelope protein E(rns).Journal of virology · 2000Article
- Perspectives for the treatment of infections with Flaviviridae.Clinical microbiology reviews · 2000Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical swine fever virus and bovine virus diarrhea virus are members of the genus pestivirus, which belongs to the family of the Flaviviridae. Recently, envelope glycoprotein Erns was identified as an RNase. RNases can express different biological actions. They have been shown to be neurotoxic, antihelminthic, and immunosuppressive. We studied the immunosuppressive properties of Erns in vitro. The glycoprotein totally inhibited concanavalin A-induced proliferation of porcine, bovine, ovine, and human lymphocytes. We then studied the direct cytotoxic effects of Erns on lymphocytes and epithelial cells in protein synthesis assays. Erns strongly inhibited the protein synthesis of lymphocytes of different species, without cell membrane damage. This suggested an apoptotic process, and indeed apoptosis of lymphocytes was detected after incubation with Erns. Pestivirus infections are characterized by leukopenia and immunosuppression. Our results suggest that Erns plays an important role in the pathogenesis of pestiviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.